Is the body composition development in premature infants associated with a distinctive nuclear magnetic resonance metabolomic profiling of urine?
J Matern Fetal Neonatal Med
; 32(14): 2310-2318, 2019 Jul.
Article
em En
| MEDLINE
| ID: mdl-29357769
ABSTRACT
OBJECTIVE:
Preterm infants' body composition at term-corrected age differs from that of term infants but appears to be similar at the age of 3 months. The aim of this study was to compare the metabolomic pattern of preterm infants at term and at 3 months with that of term infants and to determine its association with body composition development.METHOD:
We designed a pilot study. Growth and body composition were evaluated by an air displacement plethysmography system in 13 preterm infants and seven term newborns at term and at 3 months of corrected age. Urine samples were collected at the same time points and analysed by nuclear magnetic resonance.RESULTS:
At term-corrected age, preterm infants showed a higher fat mass percentage compared with that of term newborns, whereas at 3 months of corrected age, the body composition parameters were similar between the groups. At the first time point, nuclear magnetic resonance analysis showed a urinary increase in choline/phosphocholine, betaine and glucose in preterm infants. At the second time point, the preterm group exhibited a urinary increase in choline/phosphocholine and a decrease in betaine.CONCLUSIONS:
The increased urinary excretion of choline, a betaine precursor, could reflect a potential altered metabolism in preterm infants.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Urina
/
Composição Corporal
/
Recém-Nascido Prematuro
/
Recém-Nascido de muito Baixo Peso
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Humans
/
Infant
/
Newborn
Idioma:
En
Revista:
J Matern Fetal Neonatal Med
Assunto da revista:
OBSTETRICIA
/
PERINATOLOGIA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Itália