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Expression of Hippo signaling pathway and Aurora kinase genes in chronic myeloid leukemia.
Marsola, Ana Paula Zambuzi Cardoso; Simões, Belinda Pinto; Palma, Leonardo Carvalho; Berzoti-Coelho, Maria Gabriela; Burin, Sandra Mara; de Castro, Fabíola Attié.
Afiliação
  • Marsola APZC; Department of Clinical Analysis, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo-USP, Café Avenue, Ribeirão Preto, SP, Brazil. anafarma_usp@yahoo.com.br.
  • Simões BP; Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo-USP, 3900 Bandeirantes Avenue, Ribeirão Preto, SP, Brazil.
  • Palma LC; Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo-USP, 3900 Bandeirantes Avenue, Ribeirão Preto, SP, Brazil.
  • Berzoti-Coelho MG; Department of Clinical Analysis, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo-USP, Café Avenue, Ribeirão Preto, SP, Brazil.
  • Burin SM; Department of Clinical Analysis, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo-USP, Café Avenue, Ribeirão Preto, SP, Brazil.
  • de Castro FA; Department of Clinical Analysis, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo-USP, Café Avenue, Ribeirão Preto, SP, Brazil.
Med Oncol ; 35(3): 26, 2018 Jan 31.
Article em En | MEDLINE | ID: mdl-29387948
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm resulting from clonal expansion of hematopoietic stem cells positive for the Philadelphia chromosome. The CML pathogenesis is associated with expression of the BCR-ABL1 oncogene, which encodes the Bcr-Abl protein with tyrosine kinase activity, promoting the leukemic cell exacerbated myeloproliferation and resistance to apoptosis. CML patients are usually treated with tyrosine kinase inhibitors (TKI), but some of them acquire resistance or are refractory to TKI. Thus, it is still relevant to elucidate the CML pathogenesis and seek new therapeutic targets, such as the Hippo signaling pathway and cell cycle regulatory genes from the Aurora kinase family. The present study quantified the expression level of genes encoding components of the Hippo signaling pathway (LATS1, LATS2, YAP, and TAZ), AURKA and AURKB in CML patients at different stages of the disease, who were resistant or sensitive to imatinib mesylate therapy, and in healthy individuals. The expression levels of the target genes were correlated with the CML Sokal's prognostic score. The most striking results were the LATS2 and AURKA overexpression in CML patients, the overexpression of TAZ and AURKB in CML patients at advanced phases and TAZ in CML IM-resistant. The development of drugs and/or identification of tumor markers for the Hippo signaling pathway and the Aurora kinase family, either alone or in combination, can optimize CML treatment by enhancing the susceptibility of leukemic cells to apoptosis and leading to a better disease prognosis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Mielogênica Crônica BCR-ABL Positiva / Biomarcadores Tumorais / Regulação Leucêmica da Expressão Gênica / Proteínas Serina-Treonina Quinases / Resistencia a Medicamentos Antineoplásicos / Aurora Quinase A / Aurora Quinase B Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Med Oncol Assunto da revista: NEOPLASIAS Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Mielogênica Crônica BCR-ABL Positiva / Biomarcadores Tumorais / Regulação Leucêmica da Expressão Gênica / Proteínas Serina-Treonina Quinases / Resistencia a Medicamentos Antineoplásicos / Aurora Quinase A / Aurora Quinase B Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Med Oncol Assunto da revista: NEOPLASIAS Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil