Isoxazole-containing neonicotinoids: Design, synthesis, and insecticidal evaluation.

Lei, Chao; Geng, Li; Xu, Xiaoyong; Shao, Xusheng; Li, Zhong

Lei, Chao; Geng, Li; Xu, Xiaoyong; Shao, Xusheng; Li, Zhong.

Afiliação

Lei C; Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
Geng L; Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
Xu X; Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
Shao X; Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
Li Z; Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China; Shanghai Collaborative Innovation Center for Biomanufacturing Technology, 130 Meilong Road, Shanghai 200237, China. Electronic address: lizhong@ecust.edu.cn.

Bioorg Med Chem Lett ; 28(4): 831-833, 2018 02 15.

Article em En | MEDLINE | ID: mdl-29402746

ABSTRACT

ABSTRACT

A series of novel isoxazole-containing neonicotinoids were synthesized from nitromethylene analogues and aromatic aldehydes in the presence of l-proline/K2CO3. Bioassays indicated that several synthesized compounds showed 40-70% mortality against brown planthopper (Nilaparvata lugens) under the concentration of 4mgL-1, higher than that of imidacloprid (20%). Against cowpea aphid (Aphis craccivora), the best activity of title compounds reached 90% at the concentration of 20mgL-1.

Assuntos

Inseticidas/farmacologia; Isoxazóis/farmacologia; Neonicotinoides/farmacologia; Animais; Afídeos/efeitos dos fármacos; Bioensaio; Desenho de Fármacos; Hemípteros/efeitos dos fármacos; Inseticidas/síntese química; Inseticidas/química; Isoxazóis/síntese química; Isoxazóis/química; Estrutura Molecular; Neonicotinoides/síntese química; Neonicotinoides/química; Nitrocompostos/farmacologia

Palavras-chave

Imidacloprid; Insecticidal activity; Isoxazole; Neonicotinoids; Synthesis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neonicotinoides / Inseticidas / Isoxazóis Limite: Animals Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China

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