Diastereo- and Enantioselective Synthesis of Spirooxindoles with Contiguous Tetrasubstituted Stereocenters via Catalytic Coupling of Two Tertiary Radicals.
J Org Chem
; 83(5): 2966-2970, 2018 03 02.
Article
em En
| MEDLINE
| ID: mdl-29405713
ABSTRACT
The oxidative N-heterocyclic carbene-catalyzed [3 + 2] annulation of ß,ß-disubstituted enals and dioxindoles was developed, giving the spirocyclic oxindole-γ-lactones bearing two contiguous tetrasubstituted stereocenters in good yields with excellent diastereoselectivities and good enantioselectivities.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
China