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Digoxin Suppresses Pyruvate Kinase M2-Promoted HIF-1α Transactivation in Steatohepatitis.
Ouyang, Xinshou; Han, Sheng-Na; Zhang, Ji-Yuan; Dioletis, Evangelos; Nemeth, Balazs Tamas; Pacher, Pal; Feng, Dechun; Bataller, Ramon; Cabezas, Joaquin; Stärkel, Peter; Caballeria, Joan; Pongratz, Rebecca LePine; Cai, Shi-Ying; Schnabl, Bernd; Hoque, Rafaz; Chen, Yonglin; Yang, Wei-Hong; Garcia-Martinez, Irma; Wang, Fu-Sheng; Gao, Bin; Torok, Natalie Julia; Kibbey, Richard Glenn; Mehal, Wajahat Zafar.
Afiliação
  • Ouyang X; Section of Digestive Diseases, Yale University, New Haven, CT 06520, USA. Electronic address: xinshou.ouyang@yale.edu.
  • Han SN; Section of Digestive Diseases, Yale University, New Haven, CT 06520, USA.
  • Zhang JY; Section of Digestive Diseases, Yale University, New Haven, CT 06520, USA.
  • Dioletis E; Section of Digestive Diseases, Yale University, New Haven, CT 06520, USA.
  • Nemeth BT; Laboratory of Cardiovascular Physiology and Tissue Injury, NIAAA/NIH, Bethesda, MD 20892, USA.
  • Pacher P; Laboratory of Cardiovascular Physiology and Tissue Injury, NIAAA/NIH, Bethesda, MD 20892, USA.
  • Feng D; NIAAA, NIH, 5625 Fishers Lane, Bethesda, MD 20892, USA.
  • Bataller R; Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
  • Cabezas J; Division of Gastroenterology and Hepatology, Department of Medicine, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Stärkel P; Department of Gastroenterology, Saint-Luc Academic Hospital and Institute of Clinical Research, Catholic University of Louvain, Brussels, Belgium.
  • Caballeria J; Unidad de Hepatología, Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain.
  • Pongratz RL; Cellular and Molecular Physiology, Yale University, New Haven, CT 06520, USA.
  • Cai SY; Section of Digestive Diseases, Yale University, New Haven, CT 06520, USA.
  • Schnabl B; Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
  • Hoque R; Section of Digestive Diseases, Yale University, New Haven, CT 06520, USA.
  • Chen Y; Section of Digestive Diseases, Yale University, New Haven, CT 06520, USA.
  • Yang WH; Section of Digestive Diseases, Yale University, New Haven, CT 06520, USA.
  • Garcia-Martinez I; Section of Digestive Diseases, Yale University, New Haven, CT 06520, USA.
  • Wang FS; Institute of Translational Hepatology, Beijing 302 Hospital, Beijing 100039, China.
  • Gao B; NIAAA, NIH, 5625 Fishers Lane, Bethesda, MD 20892, USA.
  • Torok NJ; Department of Medicine, Gastroenterology, and Hepatology, University of California, Davis, Sacramento, CA, USA.
  • Kibbey RG; Cellular and Molecular Physiology, Yale University, New Haven, CT 06520, USA.
  • Mehal WZ; Section of Digestive Diseases, Yale University, New Haven, CT 06520, USA; West Haven Veterans Medical Center, West Haven, CT 06516, USA. Electronic address: wajahat.mehal@yale.edu.
Cell Metab ; 27(2): 339-350.e3, 2018 02 06.
Article em En | MEDLINE | ID: mdl-29414684
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piruvato Quinase / Ativação Transcricional / Digoxina / Subunidade alfa do Fator 1 Induzível por Hipóxia / Hepatopatia Gordurosa não Alcoólica Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cell Metab Assunto da revista: METABOLISMO Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piruvato Quinase / Ativação Transcricional / Digoxina / Subunidade alfa do Fator 1 Induzível por Hipóxia / Hepatopatia Gordurosa não Alcoólica Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cell Metab Assunto da revista: METABOLISMO Ano de publicação: 2018 Tipo de documento: Article