Identification of a staphylococcal complement inhibitor with broad host specificity in equid <i>Staphylococcus aureus</i> strains.

de Jong, Nienke W M; Vrieling, Manouk; Garcia, Brandon L; Koop, Gerrit; Brettmann, Matt; Aerts, Piet C; Ruyken, Maartje; van Strijp, Jos A G; Holmes, Mark; Harrison, Ewan M; Geisbrecht, Brian V; Rooijakkers, Suzan H M

Identification of a staphylococcal complement inhibitor with broad host specificity in equid Staphylococcus aureus strains.

de Jong, Nienke W M; Vrieling, Manouk; Garcia, Brandon L; Koop, Gerrit; Brettmann, Matt; Aerts, Piet C; Ruyken, Maartje; van Strijp, Jos A G; Holmes, Mark; Harrison, Ewan M; Geisbrecht, Brian V; Rooijakkers, Suzan H M.

Afiliação

de Jong NWM; From the Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands.
Vrieling M; From the Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands.
Garcia BL; the Roslin Institute, University of Edinburgh, Easter Bush Campus, Midlothian EH25 9RG, United Kingdom.
Koop G; the Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, Kansas 66506.
Brettmann M; the Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The Netherlands.
Aerts PC; the Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, Kansas 66506.
Ruyken M; From the Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands.
van Strijp JAG; From the Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands.
Holmes M; From the Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands.
Harrison EM; the Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, United Kingdom, and.
Geisbrecht BV; the Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom.
Rooijakkers SHM; the Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, Kansas 66506.

J Biol Chem ; 293(12): 4468-4477, 2018 03 23.

Article em En | MEDLINE | ID: mdl-29414776

Assuntos

Convertases de Complemento C3-C5/metabolismo; Complemento C3b/antagonistas & inibidores; Proteínas Inativadoras do Complemento/metabolismo; Infecções Estafilocócicas/microbiologia; Staphylococcus aureus/metabolismo; Fatores de Virulência/metabolismo; Animais; Complemento C3b/metabolismo; Proteínas Inativadoras do Complemento/química; Hemólise; Cavalos; Especificidade de Hospedeiro; Humanos; Fagocitose; Ligação Proteica; Infecções Estafilocócicas/metabolismo; Staphylococcus aureus/isolamento & purificação; Suínos; Fatores de Virulência/química

Palavras-chave

SCIN; Staphylococcus aureus (S. aureus); complement system; equine; host adaptation; host-pathogen interaction; immune evasion; innate immunity; microbial pathogenesis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Estafilocócicas / Staphylococcus aureus / Proteínas Inativadoras do Complemento / Complemento C3b / Fatores de Virulência / Convertases de Complemento C3-C5 Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Holanda

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