Taurine as a protective agent for 5-fluorouracil-induced hepatic damage related to oxidative stress.
Pharmazie
; 71(9): 530-532, 2016 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-29441849
ABSTRACT
5-Fluorouracil (5-FU) is a pyrimidine analog widely used for the treatment of various cancers, but often causes hepatic damage in clinical practice. In this study, we examined the influence of taurine on 5-FU-induced hepatotoxicity in mice with respect to changes in oxidative stress. Elevations in the aspartate aminotransferase and alanine aminotransferase serum levels after 5-FU administration were significantly suppressed in a dosedependent manner by concurrent treatment with taurine. The activity of superoxide dismutase and reduced glutathione content in the liver were significantly decreased following treatment with 5-FU alone, but these changes were markedly inhibited by the administration of taurine. Our findings suggest that taurine protects against 5-FU-induced hepatotoxicity by suppressing oxidative stress.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Taurina
/
Substâncias Protetoras
/
Doença Hepática Induzida por Substâncias e Drogas
/
Fluoruracila
/
Antimetabólitos Antineoplásicos
Limite:
Animals
Idioma:
En
Revista:
Pharmazie
Assunto da revista:
FARMACIA
Ano de publicação:
2016
Tipo de documento:
Article