Exploring the Metabolism of (+)-[<sup>18</sup>F]Flubatine in Vitro and in Vivo: LC-MS/MS Aided Identification of Radiometabolites in a Clinical PET Study.

Ludwig, Friedrich-Alexander; Fischer, Steffen; Smits, René; Deuther-Conrad, Winnie; Hoepping, Alexander; Tiepolt, Solveig; Patt, Marianne; Sabri, Osama; Brust, Peter

Exploring the Metabolism of (+)-[¹⁸F]Flubatine in Vitro and in Vivo: LC-MS/MS Aided Identification of Radiometabolites in a Clinical PET Study.

Ludwig, Friedrich-Alexander; Fischer, Steffen; Smits, René; Deuther-Conrad, Winnie; Hoepping, Alexander; Tiepolt, Solveig; Patt, Marianne; Sabri, Osama; Brust, Peter.

Afiliação

Ludwig FA; Helmholtz-Zentrum Dresden-Rossendorf, Research Site Leipzig, Institute of Radiopharmaceutical Cancer Research, Permoserstraße 15, Leipzig 04318, Germany. f.ludwig@hzdr.de.
Fischer S; Helmholtz-Zentrum Dresden-Rossendorf, Research Site Leipzig, Institute of Radiopharmaceutical Cancer Research, Permoserstraße 15, Leipzig 04318, Germany. s.fischer@hzdr.de.
Smits R; ABX advanced biochemical compounds GmbH, Heinrich-Gläser-Straße 10-14, Radeberg 01454, Germany. smits@abx.de.
Deuther-Conrad W; Helmholtz-Zentrum Dresden-Rossendorf, Research Site Leipzig, Institute of Radiopharmaceutical Cancer Research, Permoserstraße 15, Leipzig 04318, Germany. w.deuther-conrad@hzdr.de.
Hoepping A; ABX advanced biochemical compounds GmbH, Heinrich-Gläser-Straße 10-14, Radeberg 01454, Germany. hoepping@abx.de.
Tiepolt S; Department of Nuclear Medicine, University Hospital Leipzig, Liebigstraße 18, Leipzig 04103, Germany. solveig.tiepolt@medizin.uni-leipzig.de.
Patt M; Department of Nuclear Medicine, University Hospital Leipzig, Liebigstraße 18, Leipzig 04103, Germany. marianne.patt@medizin.uni-leipzig.de.
Sabri O; Department of Nuclear Medicine, University Hospital Leipzig, Liebigstraße 18, Leipzig 04103, Germany. osama.sabri@medizin.uni-leipzig.de.
Brust P; Helmholtz-Zentrum Dresden-Rossendorf, Research Site Leipzig, Institute of Radiopharmaceutical Cancer Research, Permoserstraße 15, Leipzig 04318, Germany. p.brust@hzdr.de.

Molecules ; 23(2)2018 Feb 20.

Article em En | MEDLINE | ID: mdl-29461507

Assuntos

Benzamidas/metabolismo; Compostos Bicíclicos Heterocíclicos com Pontes/metabolismo; Neuroimagem; Tomografia por Emissão de Pósitrons; Receptores Nicotínicos/química; Animais; Benzamidas/administração & dosagem; Compostos Bicíclicos Heterocíclicos com Pontes/administração & dosagem; Cromatografia Líquida; Humanos; Metaboloma/genética; Receptores Nicotínicos/isolamento & purificação; Suínos/sangue; Suínos/urina; Espectrometria de Massas em Tandem

Palavras-chave

NCFHEB; [18F]FLBT; [18F]flubatine; glucuronides; liquid chromatographytandem mass spectrometry (LC-MS/MS); liver microsomes; nicotinic acetylcholine receptors (nAChRs); positron emission tomography (PET); radiometabolites

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzamidas / Receptores Nicotínicos / Compostos Bicíclicos Heterocíclicos com Pontes / Tomografia por Emissão de Pósitrons / Neuroimagem Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Alemanha

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