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Glutaminolysis is a metabolic dependency in FLT3ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition.
Gallipoli, Paolo; Giotopoulos, George; Tzelepis, Konstantinos; Costa, Ana S H; Vohra, Shabana; Medina-Perez, Paula; Basheer, Faisal; Marando, Ludovica; Di Lisio, Lorena; Dias, Joao M L; Yun, Haiyang; Sasca, Daniel; Horton, Sarah J; Vassiliou, George; Frezza, Christian; Huntly, Brian J P.
Afiliação
  • Gallipoli P; Wellcome Trust-MRC Cambridge Stem Cell Institute, Cambridge, United Kingdom.
  • Giotopoulos G; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.
  • Tzelepis K; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge, United Kingdom.
  • Costa ASH; Wellcome Trust-MRC Cambridge Stem Cell Institute, Cambridge, United Kingdom.
  • Vohra S; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.
  • Medina-Perez P; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge, United Kingdom.
  • Basheer F; Haematological Cancer Genetics, Wellcome Trust Sanger Institute-Hinxton, Cambridge, United Kingdom.
  • Marando L; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge Biomedical Campus, Cambridge, United Kingdom; and.
  • Di Lisio L; Wellcome Trust-MRC Cambridge Stem Cell Institute, Cambridge, United Kingdom.
  • Dias JML; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.
  • Yun H; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge, United Kingdom.
  • Sasca D; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, United Kingdom.
  • Horton SJ; Wellcome Trust-MRC Cambridge Stem Cell Institute, Cambridge, United Kingdom.
  • Vassiliou G; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.
  • Frezza C; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge, United Kingdom.
  • Huntly BJP; Wellcome Trust-MRC Cambridge Stem Cell Institute, Cambridge, United Kingdom.
Blood ; 131(15): 1639-1653, 2018 04 12.
Article em En | MEDLINE | ID: mdl-29463564
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Inibidores de Proteínas Quinases / Tirosina Quinase 3 Semelhante a fms / Glutamina / Mutação Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Blood Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Inibidores de Proteínas Quinases / Tirosina Quinase 3 Semelhante a fms / Glutamina / Mutação Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Blood Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Reino Unido