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Regulation of the Cell Biology of Antigen Cross-Presentation.
Blander, J Magarian.
Afiliação
  • Blander JM; Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; email: jmblander@med.cornell.edu.
Annu Rev Immunol ; 36: 717-753, 2018 04 26.
Article em En | MEDLINE | ID: mdl-29490164
Antigen cross-presentation is an adaptation of the cellular process of loading MHC-I molecules with endogenous peptides during their biosynthesis within the endoplasmic reticulum. Cross-presented peptides derive from internalized proteins, microbial pathogens, and transformed or dying cells. The physical separation of internalized cargo from the endoplasmic reticulum, where the machinery for assembling peptide-MHC-I complexes resides, poses a challenge. To solve this problem, deliberate rewiring of organelle communication within cells is necessary to prepare for cross-presentation, and different endocytic receptors and vesicular traffic patterns customize the emergent cross-presentation compartment to the nature of the peptide source. Three distinct pathways of vesicular traffic converge to form the ideal cross-presentation compartment, each regulated differently to supply a unique component that enables cross-presentation of a diverse repertoire of peptides. Delivery of centerpiece MHC-I molecules is the critical step regulated by microbe-sensitive Toll-like receptors. Defining the subcellular sources of MHC-I and identifying sites of peptide loading during cross-presentation remain key challenges.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apresentação de Antígeno / Apresentação Cruzada / Imunomodulação / Antígenos Limite: Animals / Humans Idioma: En Revista: Annu Rev Immunol Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apresentação de Antígeno / Apresentação Cruzada / Imunomodulação / Antígenos Limite: Animals / Humans Idioma: En Revista: Annu Rev Immunol Ano de publicação: 2018 Tipo de documento: Article