Clinical and histological features of second breast cancers following radiotherapy for childhood and young adult malignancy.
Br J Radiol
; 91(1086): 20170824, 2018 Jun.
Article
em En
| MEDLINE
| ID: mdl-29493262
ABSTRACT
OBJECTIVE:
The purpose of this study was to determine the characteristics of early second breast cancer (SBC) among survivors of childhood and young adult malignancy treated with irradiation.METHODS:
We conducted a multicenter retrospective study of women who presented with breast cancer aged 50 years or younger in nine French centers.RESULTS:
121 patients and 141 SBC were analyzed (invasive = 130; non-invasive = 11). The mean age at first cancer diagnosis was 15 years and at initial SBC diagnosis was 38 years. Bilateral disease before the age of 51 years was diagnosed in 16% of the females. The majority of SBC were invasive carcinomas (92%). Among the invasive carcinomas, 39% had a histoprognostic score of III, 3.1% overexpressed HER2 and 29% were triple negative. The proportion of triple negative phenotype SBC was higher in patients older at first cancer diagnosis [RR = 1.2, 95% CI (1.1-1.3)]. 94% of triple negative SBCs developed in breast tissue which had received >20 Gy.CONCLUSION:
We found a high proportion of aggressive SBC following thoracic radiotherapy in childhood or early adulthood. Advances in knowledge SBC screening is recommended by scientific societies for these child/young-adulthood cancer survivors in the same way as the one for high risk women because of constitutional mutations. Our results support these recommendations, not only because of a similar cumulative risk, but also because of the aggressive histological characteristics.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Radiografia Torácica
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Segunda Neoplasia Primária
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Sobreviventes de Câncer
Tipo de estudo:
Etiology_studies
/
Guideline
/
Observational_studies
/
Risk_factors_studies
Limite:
Adolescent
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Adult
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Child
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Child, preschool
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Female
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Humans
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Infant
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Middle aged
Idioma:
En
Revista:
Br J Radiol
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
França