Allelic frequencies of 60 pharmacogene variants assessed within a Burmese population residing in northeast Indiana, USA.
Pharmacogenomics
; 19(5): 393-399, 2018 04.
Article
em En
| MEDLINE
| ID: mdl-29517466
ABSTRACT
AIM:
The aim of this study was to investigate 60 SNPs pertaining to drug metabolism and pharmacodynamics in the Burmese refugee population in the Fort Wayne, Indiana area to better inform patient care. MATERIALS &METHODS:
Sixty-two self-identified Burmese refugees were genotyped for 60 common SNPs pertaining to pharmacokinetic and pharmacodynamic pharmacogenes. The resulting allelic frequencies were compared with Ensembl's database for surrounding populations to Myanmar and America.RESULTS:
The frequency of OPRM1, CYP2D6, SLCO1B1, MTHFR and VKORC1 were approximately 20% different in the Burmese refugee population as compared with the Ensembl populations.CONCLUSION:
Our study demonstrates that genetic differences are expected to affect drug efficacy in patients with a Burmese background.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Frequência do Gene
Limite:
Adult
/
Female
/
Humans
/
Male
País/Região como assunto:
America do norte
/
Asia
Idioma:
En
Revista:
Pharmacogenomics
Assunto da revista:
FARMACOLOGIA
/
GENETICA MEDICA
Ano de publicação:
2018
Tipo de documento:
Article