[Acute hypersensitivity reactions associated with monoclonal antibodies for targeted therapy]. / Akute Überempfindlichkeitsreaktionen auf monoklonale Antikörper zur zielgerichteten Therapie.
Hautarzt
; 69(4): 268-277, 2018 Apr.
Article
em De
| MEDLINE
| ID: mdl-29520502
ABSTRACT
The application of biologics such as monoclonal antibodies for targeted therapy may lead to immediate adverse drug reactions with different pathophysiological mechanisms. Some of them are due to the immunogenicity of these drugs and are truly allergic, some of them are non-allergic, some are on-target, and some are off-target. The main example of non-allergic reactions are infusion reactions, mainly induced by cytokine release. They generally occur already at the first application and symptoms may decrease in subsequent applications. Allergic reactions need a preceding sensitization phase and therefore may not occur at first application. However, if the IgE-mediated reaction is due to cross-reactivity, they may occur at the first application of the monoclonal antibody. The management of these reactions depends on their severity and the ultimate need to treat the patient with these drugs.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hipersensibilidade a Drogas
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Hipersensibilidade
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Anafilaxia
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Anticorpos Monoclonais
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
De
Revista:
Hautarzt
Ano de publicação:
2018
Tipo de documento:
Article