Using Metagenomics to Characterize an Expanding Virosphere.

Zhang, Yong-Zhen; Shi, Mang; Holmes, Edward C

Zhang, Yong-Zhen; Shi, Mang; Holmes, Edward C.

Afiliação

Zhang YZ; Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Fudan University, Shanghai, China; State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing, China. Electronic address: zhangyongzhen@shphc.org.cn.
Shi M; Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Fudan University, Shanghai, China; State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing, China; Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre,
Holmes EC; Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Fudan University, Shanghai, China; State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing, China; Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre,

Cell ; 172(6): 1168-1172, 2018 03 08.

Article em En | MEDLINE | ID: mdl-29522738

ABSTRACT

ABSTRACT

We know less about viruses than any other lifeform. Fortunately, metagenomics has led to a massive expansion in the known diversity of the virosphere. Here, we discuss how metagenomics has changed our understanding of RNA viruses and present some of the remaining challenges, including characterization of the "dark matter" of divergent viral genomes.

Assuntos

Variação Genética; Genoma Viral/genética; Metagenômica/métodos; Vírus/genética; Evolução Molecular; Filogenia; Vírus de RNA/classificação; Vírus de RNA/genética; Vírus/classificação

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Variação Genética / Vírus / Genoma Viral / Metagenômica Idioma: En Revista: Cell Ano de publicação: 2018 Tipo de documento: Article

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