Interleukin-10 rs1800871 (-819C/T) and ATA haplotype are associated with preeclampsia in a Tunisian population.
Pregnancy Hypertens
; 11: 105-110, 2018 Jan.
Article
em En
| MEDLINE
| ID: mdl-29523264
ABSTRACT
OBJECTIVES:
Interleukin-10 (IL-10) is implicated in several aspects of pregnancy. As genetic predisposition can be involved in the development of preeclampsia, the association between IL-10's promoter region polymorphisms and this pathology has been investigated, although with conflicting results. To date, only a small cohort study (total nâ¯=â¯40) has evaluated this association in the African continent, and none have been conducted in Tunisia. Hence, we evaluated the association between these polymorphisms and the risk of preeclampsia in a large Tunisian cohort. STUDYDESIGN:
345 preeclampsia patients and 300 controls were genotyped for the IL-10 promoter region variants -1082A/G, -819C/T and -592A/C using real-time PCR. MAIN OUTCOMEMEASURES:
Differences in means were determined by Student's t-test, while intergroup significance was assessed by Pearson χ2 or 2-way ANOVA. Genotypes were tested for Hardy-Weinberg equilibrium (HWE) in the control and cases. Logistic regression analysis was performed in order to determine the odds ratios and 95% confidence intervals associated with the linkage disequilibrium risk.RESULTS:
An increased frequency of the -819â¯T (minor) allele and the -819â¯T/T genotype was seen in preeclampsia cases. Also, three-locus haplotype (-1082AG/-819CT/-592AC) analysis identified the ATA haplotype as having a higher incidence in women with preeclampsia (ORâ¯=â¯1.48, 95% CI 1.03-2.11) and this was confirmed by multivariate regression analysis (ORâ¯=â¯1.65, 95% CI 1.13-2.43) after controlling for covariates.CONCLUSIONS:
We suggest that the IL-10 -819â¯T/T variant and the ATA haplotype, which are associated with low production of IL 10, represent genetic risk factors for preeclampsia in Tunisian women.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pré-Eclâmpsia
/
Pressão Sanguínea
/
Haplótipos
/
Interleucina-10
/
Polimorfismo de Nucleotídeo Único
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Pregnancy
País/Região como assunto:
Africa
Idioma:
En
Revista:
Pregnancy Hypertens
Ano de publicação:
2018
Tipo de documento:
Article