The Effect of Vasectomy Reversal on Prostate Cancer Risk: International Meta-Analysis of 684,660 Vasectomized Men.
J Urol
; 200(1): 121-125, 2018 07.
Article
em En
| MEDLINE
| ID: mdl-29524505
ABSTRACT
PURPOSE:
Evidence of the effect of vasectomy on prostate cancer is conflicting with the issue of detection bias a key criticism. We examined the effect of vasectomy reversal on prostate cancer risk in a cohort of vasectomized men. Evidence of a protective effect would be consistent with a harmful effect of vasectomy on prostate cancer risk while nullifying the issue of detection bias. MATERIALS ANDMETHODS:
Data were sourced from a total of 5 population level linked health databases in Australia, Canada and the United Kingdom. Cox proportional hazards regression analysis was used to compare the risk of prostate cancer in 9,754 men with vasectomy reversal to the risk in 684,660 with vasectomy but no reversal. Data from each jurisdiction were combined in a meta-analysis.RESULTS:
The combined analysis showed no protective effect of vasectomy reversal on the incidence of prostate cancer compared to that in men with vasectomy alone (HR 0.92, 95% CI 0.70-1.21).CONCLUSIONS:
These results align with those of previous studies showing no evidence of a link between vasectomy and prostate cancer.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
/
Vasectomia
/
Vasovasostomia
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Prognostic_studies
/
Systematic_reviews
Limite:
Adult
/
Humans
/
Male
País/Região como assunto:
America do norte
/
Europa
/
Oceania
Idioma:
En
Revista:
J Urol
Ano de publicação:
2018
Tipo de documento:
Article