A Novel TGFß Trap Blocks Chemotherapeutics-Induced TGFß1 Signaling and Enhances Their Anticancer Activity in Gynecologic Cancers.

Zhu, Haiyan; Gu, Xiang; Xia, Lu; Zhou, You; Bouamar, Hakim; Yang, Junhua; Ding, Xiaofei; Zwieb, Christian; Zhang, Jianan; Hinck, Andrew P; Sun, Lu-Zhe; Zhu, Xueqiong

Zhu, Haiyan; Gu, Xiang; Xia, Lu; Zhou, You; Bouamar, Hakim; Yang, Junhua; Ding, Xiaofei; Zwieb, Christian; Zhang, Jianan; Hinck, Andrew P; Sun, Lu-Zhe; Zhu, Xueqiong.

Afiliação

Zhu H; Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Gu X; Department of Cell Systems & Anatomy, School of Medicine, University of Texas Health Science Center at San Antonio, Texas.
Xia L; Department of Cell Systems & Anatomy, School of Medicine, University of Texas Health Science Center at San Antonio, Texas.
Zhou Y; Department of Cell Systems & Anatomy, School of Medicine, University of Texas Health Science Center at San Antonio, Texas.
Bouamar H; Department of Gynecology and Obstetrics, Xiangya Hospital and Xiangya School of Medicine, Central South University, Hunan, China.
Yang J; Department of Cell Systems & Anatomy, School of Medicine, University of Texas Health Science Center at San Antonio, Texas.
Ding X; Department of Cell Systems & Anatomy, School of Medicine, University of Texas Health Science Center at San Antonio, Texas.
Zwieb C; Department of Cell Systems & Anatomy, School of Medicine, University of Texas Health Science Center at San Antonio, Texas.
Zhang J; Department of Cell Systems & Anatomy, School of Medicine, University of Texas Health Science Center at San Antonio, Texas.
Hinck AP; Department of Biochemistry, University of Texas Health Science Center at San Antonio, Texas.
Sun LZ; Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Zhu X; Department of Biochemistry, University of Texas Health Science Center at San Antonio, Texas.

Clin Cancer Res ; 24(12): 2780-2793, 2018 06 15.

Article em En | MEDLINE | ID: mdl-29549162

Assuntos

Antineoplásicos/farmacologia; Neoplasias dos Genitais Femininos/tratamento farmacológico; Neoplasias dos Genitais Femininos/metabolismo; Transdução de Sinais/efeitos dos fármacos; Fator de Crescimento Transformador beta/metabolismo; Animais; Antineoplásicos/uso terapêutico; Linhagem Celular Tumoral; Movimento Celular; Modelos Animais de Doenças; Transição Epitelial-Mesenquimal/efeitos dos fármacos; Feminino; Perfilação da Expressão Gênica; Neoplasias dos Genitais Femininos/genética; Neoplasias dos Genitais Femininos/patologia; Humanos; Camundongos; Estadiamento de Neoplasias; Células-Tronco Neoplásicas/efeitos dos fármacos; Células-Tronco Neoplásicas/metabolismo; Fosforilação; Proteína Smad2/metabolismo; Proteína Smad3/metabolismo; Transcriptoma; Fator de Crescimento Transformador beta/genética; Fator de Crescimento Transformador beta1/metabolismo; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Fator de Crescimento Transformador beta / Neoplasias dos Genitais Femininos / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Clin Cancer Res Assunto da revista: NEOPLASIAS Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China

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