Short course of simvastatin has no effect on markers of endothelial activation in normolipidemic patients with systemic sclerosis.
J Int Med Res
; 46(5): 1893-1901, 2018 May.
Article
em En
| MEDLINE
| ID: mdl-29557229
ABSTRACT
Objective Statins, a class of 3-hydroxy-3 methyl-glutaryl-coenzyme A reductase inhibitors, are widely used for the treatment of atherosclerosis. Less is known about the role of statins in the treatment of vascular complication in systemic sclerosis (SSc). We therefore performed a short-term interventional study with simvastatin in patients with the diffuse variant of SSc and normal lipid profiles. Methods Twenty-five patients with diffuse SSc were enrolled and received simvastatin at a daily dose of 20 mg for 28 days. Soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1 (sICAM-1) and soluble P-, E- and L-selectins were assessed by ELISA prior to treatment and at day 28. Results No statistically significant changes in the levels of adhesion molecules were observed sICAM-1 1011 vs. 1032 ng/mL, sVCAM-1 1225 vs. 1570 ng/mL, sP-selectin 66.7 vs. 66.0 ng/mL, sE-selectin 276 vs. 253 ng/mL and sL-selectin 887 vs. 927 ng/mL prior to treatment and at day 28, respectively. Conclusions Markers characterizing vascular activation were not affected by short treatment with low-dose simvastatin in SSc patients, indicating that the endothelial-protective effect of statins may be related to treatment duration and dose.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Escleroderma Sistêmico
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Biomarcadores
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Sinvastatina
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Células Endoteliais
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Lipídeos
Limite:
Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Int Med Res
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Polônia