Tadalafil attenuates hypotonicity-induced Ca<sup>2+</sup> influx via TRPV2 and TRPV4 in primary rat bladder urothelial cell cultures.

Dong, Xiao; Nakagomi, Hiroshi; Miyamoto, Tatsuya; Ihara, Tatsuya; Kira, Satoru; Sawada, Norifumi; Mitsui, Takahiko; Takeda, Masayuki

Tadalafil attenuates hypotonicity-induced Ca²⁺ influx via TRPV2 and TRPV4 in primary rat bladder urothelial cell cultures.

Dong, Xiao; Nakagomi, Hiroshi; Miyamoto, Tatsuya; Ihara, Tatsuya; Kira, Satoru; Sawada, Norifumi; Mitsui, Takahiko; Takeda, Masayuki.

Afiliação

Dong X; Department of Urology, the First Hospital of China Medical University, Shenyang, People's Republic of China.
Nakagomi H; Department of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi 1110 Shimokato, Chuo, Yamanashi, Japan.
Miyamoto T; Department of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi 1110 Shimokato, Chuo, Yamanashi, Japan.
Ihara T; Department of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi 1110 Shimokato, Chuo, Yamanashi, Japan.
Kira S; Department of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi 1110 Shimokato, Chuo, Yamanashi, Japan.
Sawada N; Department of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi 1110 Shimokato, Chuo, Yamanashi, Japan.
Mitsui T; Department of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi 1110 Shimokato, Chuo, Yamanashi, Japan.
Takeda M; Department of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi 1110 Shimokato, Chuo, Yamanashi, Japan.

Neurourol Urodyn ; 37(5): 1541-1548, 2018 06.

Article em En | MEDLINE | ID: mdl-29566267

Assuntos

Cálcio/metabolismo; Tono Muscular/efeitos dos fármacos; Inibidores da Fosfodiesterase 5/farmacologia; Canais de Cátion TRPV/efeitos dos fármacos; Tadalafila/farmacologia; Bexiga Urinária/efeitos dos fármacos; Urotélio/efeitos dos fármacos; Trifosfato de Adenosina/metabolismo; Animais; Células Cultivadas; Soluções Hipotônicas; Leucina/análogos & derivados; Leucina/farmacologia; Masculino; Ratos; Ratos Sprague-Dawley; Transdução de Sinais/efeitos dos fármacos; Sulfonamidas/farmacologia; Canais de Cátion TRPM/efeitos dos fármacos; Canais de Cátion TRPV/agonistas; Bexiga Urinária/citologia; Urotélio/citologia

Palavras-chave

ATP; TRP channel; lower urinary tract symptoms; phosphodiesterase type 5; tadalafil

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bexiga Urinária / Cálcio / Urotélio / Canais de Cátion TRPV / Inibidores da Fosfodiesterase 5 / Tadalafila / Tono Muscular Limite: Animals Idioma: En Revista: Neurourol Urodyn Ano de publicação: 2018 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google