S100A11 promotes TGF-ß1-induced epithelial-mesenchymal transition through SMAD2/3 signaling pathway in intrahepatic cholangiocarcinoma.
Future Oncol
; 14(9): 837-847, 2018 Apr.
Article
em En
| MEDLINE
| ID: mdl-29569474
ABSTRACT
AIM:
Our previous study found S100A11 was significantly raised in intrahepatic cholangiocarcinoma cells, but the relationship between S100A11 and intrahepatic cholangiocarcinoma remains unclear.METHODS:
We investigated the effect of silencing S100A11 on TGF-ß1-induced epithelial-mesenchymal transition (EMT), cell migration and invasion.RESULTS:
Our results demonstrated silencing S100A11 inhibited TGF-ß1-induced cell migration, invasion and EMT, expression of EMT markers E-cadherin, N-cadherin, ß-catenin, vimentin, Slug and Snail was reversed. Furthermore, TGF-ß1-induced p-SMAD2 and 3 were also inhibited due to low S100A11 expression.CONCLUSION:
Our present study indicated that S100A11 promotes EMT through accumulation of TGF-ß1 expression, and TGF-ß1-induced upregulation of p-SMAD2 and 3.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas S100
/
Colangiocarcinoma
/
Proteína Smad2
/
Fator de Crescimento Transformador beta1
Limite:
Humans
Idioma:
En
Revista:
Future Oncol
Ano de publicação:
2018
Tipo de documento:
Article