Modulation of GABA- and Glycine-Activated Ionic Currents with Semax in Isolated Cerebral Neurons.
Bull Exp Biol Med
; 164(5): 612-616, 2018 Mar.
Article
em En
| MEDLINE
| ID: mdl-29577196
ABSTRACT
The concentration-clamp experiments with neurons isolated from the rat brain showed that nootropic and neuroprotective drug Semax added to perfusion solution at concentration of 1 µM augmented the amplitude of GABA-activated ionic currents in cerebellum Purkinje cells by 147±13%. In addition, Semax in perfusion solution (0.1 and 1 µM) diminished the amplitude of glycine-activated chloride currents in hippocampal pyramidal neurons down to 68 and 43% control level, respectively. Both potentiating and inhibitory effects developed slowly, and they were poorly reversible, which indicated a probable implication of second messengers in the observed phenomena. Semax accelerated the falling edge of glycine-activated current both after a short-term co-application with agonist and after addition of this peptide into perfusion solution.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
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Cerebelo
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Hormônio Adrenocorticotrópico
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Ácido gama-Aminobutírico
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Glicina
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Hipocampo
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Neurônios
Limite:
Animals
Idioma:
En
Revista:
Bull Exp Biol Med
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Federação Russa