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Photoactivatable drugs for nicotinic optopharmacology.
Banala, Sambashiva; Arvin, Matthew C; Bannon, Nicholas M; Jin, Xiao-Tao; Macklin, John J; Wang, Yong; Peng, Can; Zhao, Guiqing; Marshall, John J; Gee, Kyle R; Wokosin, David L; Kim, Veronica J; McIntosh, J Michael; Contractor, Anis; Lester, Henry A; Kozorovitskiy, Yevgenia; Drenan, Ryan M; Lavis, Luke D.
Afiliação
  • Banala S; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia, USA.
  • Arvin MC; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  • Bannon NM; Department of Neurobiology, Weinberg School of Arts and Sciences, Northwestern University, Evanston, Illinois, USA.
  • Jin XT; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  • Macklin JJ; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia, USA.
  • Wang Y; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  • Peng C; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  • Zhao G; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  • Marshall JJ; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  • Gee KR; Molecular Probes, Thermo Fisher, Eugene, Oregon, USA.
  • Wokosin DL; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  • Kim VJ; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  • McIntosh JM; George E. Wahlen Veterans Affairs Medical Center and Departments of Psychiatry and Biology, University of Utah, Salt Lake City, Utah, USA.
  • Contractor A; Department of Neurobiology, Weinberg School of Arts and Sciences, Northwestern University, Evanston, Illinois, USA.
  • Lester HA; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  • Kozorovitskiy Y; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia, USA.
  • Drenan RM; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA.
  • Lavis LD; Department of Neurobiology, Weinberg School of Arts and Sciences, Northwestern University, Evanston, Illinois, USA.
Nat Methods ; 15(5): 347-350, 2018 05.
Article em En | MEDLINE | ID: mdl-29578537
ABSTRACT
Photoactivatable pharmacological agents have revolutionized neuroscience, but the palette of available compounds is limited. We describe a general method for caging tertiary amines by using a stable quaternary ammonium linkage that elicits a red shift in the activation wavelength. We prepared a photoactivatable nicotine (PA-Nic), uncageable via one- or two-photon excitation, that is useful to study nicotinic acetylcholine receptors (nAChRs) in different experimental preparations and spatiotemporal scales.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Nicotínicos / Processos Fotoquímicos / Nicotina Limite: Animals Idioma: En Revista: Nat Methods Assunto da revista: TECNICAS E PROCEDIMENTOS DE LABORATORIO Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Nicotínicos / Processos Fotoquímicos / Nicotina Limite: Animals Idioma: En Revista: Nat Methods Assunto da revista: TECNICAS E PROCEDIMENTOS DE LABORATORIO Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos