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Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages.
Muse, Evan D; Yu, Shan; Edillor, Chantle R; Tao, Jenhan; Spann, Nathanael J; Troutman, Ty D; Seidman, Jason S; Henke, Adam; Roland, Jason T; Ozeki, Katherine A; Thompson, Bonne M; McDonald, Jeffrey G; Bahadorani, John; Tsimikas, Sotirios; Grossman, Tamar R; Tremblay, Matthew S; Glass, Christopher K.
Afiliação
  • Muse ED; Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093.
  • Yu S; Division of Cardiovascular Diseases, Scripps Clinic, Scripps Translational Science Institute, La Jolla, CA 92037.
  • Edillor CR; California Institute for Biomedical Research, La Jolla, CA 92037.
  • Tao J; Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093.
  • Spann NJ; Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093.
  • Troutman TD; Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093.
  • Seidman JS; Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093.
  • Henke A; Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093.
  • Roland JT; California Institute for Biomedical Research, La Jolla, CA 92037.
  • Ozeki KA; California Institute for Biomedical Research, La Jolla, CA 92037.
  • Thompson BM; Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093.
  • McDonald JG; Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390.
  • Bahadorani J; Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390.
  • Tsimikas S; Department of Medicine, University of California, San Diego, La Jolla, CA 92093.
  • Grossman TR; Department of Medicine, University of California, San Diego, La Jolla, CA 92093.
  • Tremblay MS; Ionis Pharmaceuticals, Carlsbad, CA 92010.
  • Glass CK; California Institute for Biomedical Research, La Jolla, CA 92037.
Proc Natl Acad Sci U S A ; 115(20): E4680-E4689, 2018 05 15.
Article em En | MEDLINE | ID: mdl-29632203
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação da Expressão Gênica / Hepatócitos / Biomimética / Desmosterol / Proteína de Ligação a Elemento Regulador de Esterol 1 / Receptores X do Fígado / Macrófagos Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação da Expressão Gênica / Hepatócitos / Biomimética / Desmosterol / Proteína de Ligação a Elemento Regulador de Esterol 1 / Receptores X do Fígado / Macrófagos Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2018 Tipo de documento: Article