EVALUATION OF ANTI-INFLAMMATORY, ANALGESIC AND ANTIPYRETIC ACTIVITIES OF AQUEOUS AND ETHANOLIC EXTRACTS OF SEEDS OF BUCHANANIA LANZAN SPRENG. IN ANIMAL MODELS.

ABSTRACT

The present study was designed to evaluate the anti-inflammatory, analgesic and antipyretic activities of the aqueous and ethanolic extracts of seeds of Buchanania lanzan Spreng. Albino mice were used as experimental animals to evaluate these activities. The study was performed in three phases; Phase-I for evaluation of anti-inflammatory activity, Phase-II for antipyretic and Phase-HI for analgesic activities were evaluated. Carrageenan induced paw edema, brewer yeast induced pyrexia and acetic acid induced writhing methods were used to evaluate anti-inflammatory, antipyretic and analgesic activities, respectively. Tests were performed by dividing the animals in five groups. First group was negative control, second group was positive control, third, fourth and fifth groups were treated with 125, 250 and 500 mg/kg of extracts. respectively. The data were statistically analyzed using ANOVA where p < 0.05 were considered significant. The results suggested that seeds of Buchanania lanzan Spreng. possess anti-inflammatory, analgesic and antipyretic activity.