Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation.

Li, Hui; Yao, Qi; Mariscal, Alberto Garcia; Wu, Xudong; Hülse, Justus; Pedersen, Esben; Helin, Kristian; Waisman, Ari; Vinkel, Caroline; Thomsen, Simon Francis; Avgustinova, Alexandra; Benitah, Salvador Aznar; Lovato, Paola; Norsgaard, Hanne; Mortensen, Mette Sidsel; Veng, Lone; Rozell, Björn; Brakebusch, Cord

Li, Hui; Yao, Qi; Mariscal, Alberto Garcia; Wu, Xudong; Hülse, Justus; Pedersen, Esben; Helin, Kristian; Waisman, Ari; Vinkel, Caroline; Thomsen, Simon Francis; Avgustinova, Alexandra; Benitah, Salvador Aznar; Lovato, Paola; Norsgaard, Hanne; Mortensen, Mette Sidsel; Veng, Lone; Rozell, Björn; Brakebusch, Cord.

Afiliação

Li H; Department of Biomedical Sciences, University of Copenhagen, Ole Maaløes Vej 5, 2200, Copenhagen, Denmark.
Yao Q; Biotech Research and Innovation Centre (BRIC), Ole Maaløes Vej 5, 2200, Copenhagen, Denmark.
Mariscal AG; Department of Biomedical Sciences, University of Copenhagen, Ole Maaløes Vej 5, 2200, Copenhagen, Denmark.
Wu X; Biotech Research and Innovation Centre (BRIC), Ole Maaløes Vej 5, 2200, Copenhagen, Denmark.
Hülse J; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, 2200, Denmark.
Pedersen E; Department of Biomedical Sciences, University of Copenhagen, Ole Maaløes Vej 5, 2200, Copenhagen, Denmark.
Helin K; Biotech Research and Innovation Centre (BRIC), Ole Maaløes Vej 5, 2200, Copenhagen, Denmark.
Waisman A; Biotech Research and Innovation Centre (BRIC), Ole Maaløes Vej 5, 2200, Copenhagen, Denmark.
Vinkel C; Centre for Epigenetics, Ole Maaløes Vej 5, 2200, Copenhagen, Denmark.
Thomsen SF; Department of Biomedical Sciences, University of Copenhagen, Ole Maaløes Vej 5, 2200, Copenhagen, Denmark.
Avgustinova A; Biotech Research and Innovation Centre (BRIC), Ole Maaløes Vej 5, 2200, Copenhagen, Denmark.
Benitah SA; Department of Biomedical Sciences, University of Copenhagen, Ole Maaløes Vej 5, 2200, Copenhagen, Denmark.
Lovato P; Biotech Research and Innovation Centre (BRIC), Ole Maaløes Vej 5, 2200, Copenhagen, Denmark.
Norsgaard H; Biotech Research and Innovation Centre (BRIC), Ole Maaløes Vej 5, 2200, Copenhagen, Denmark.
Mortensen MS; Centre for Epigenetics, Ole Maaløes Vej 5, 2200, Copenhagen, Denmark.
Veng L; Institute for Molecular Medicine, Johannes Gutenberg-University Mainz, Obere Zahlbacher Straße 67, 55131, Mainz, Germany.
Rozell B; Department of Dermatology, Copenhagen University Hospital Bispebjerg, Bispebjerg Bakke 23, 2400, Copenhagen, Denmark.
Brakebusch C; Department of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3, 2200, Copenhagen, Denmark.

Nat Commun ; 9(1): 1420, 2018 04 12.

Article em En | MEDLINE | ID: mdl-29650963

Assuntos

Epigênese Genética; Histona-Lisina N-Metiltransferase/genética; Subunidade p19 da Interleucina-23/genética; Psoríase/genética; Pele/metabolismo; Proteína Neuronal da Síndrome de Wiskott-Aldrich/genética; Adulto; Animais; Modelos Animais de Doenças; Genes Reporter; Proteínas de Fluorescência Verde/genética; Proteínas de Fluorescência Verde/metabolismo; Células HEK293; Histona-Lisina N-Metiltransferase/deficiência; Histona-Lisina N-Metiltransferase/metabolismo; Histonas/genética; Histonas/metabolismo; Humanos; Inflamação; Interleucina-17/genética; Interleucina-17/metabolismo; Subunidade p19 da Interleucina-23/deficiência; Queratinócitos/metabolismo; Queratinócitos/patologia; Masculino; Camundongos; Camundongos Knockout; Pessoa de Meia-Idade; Cultura Primária de Células; Regiões Promotoras Genéticas; Psoríase/metabolismo; Psoríase/patologia; Transdução de Sinais; Pele/patologia; Proteína Neuronal da Síndrome de Wiskott-Aldrich/deficiência

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Psoríase / Pele / Histona-Lisina N-Metiltransferase / Epigênese Genética / Proteína Neuronal da Síndrome de Wiskott-Aldrich / Subunidade p19 da Interleucina-23 Limite: Adult / Animals / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Dinamarca

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