Analysis of the Indacaterol-Regulated Transcriptome in Human Airway Epithelial Cells Implicates Gene Expression Changes in the Adverse and Therapeutic Effects of <i>ß</i><sub>2</sub>-Adrenoceptor Agonists.

Yan, Dong; Hamed, Omar; Joshi, Taruna; Mostafa, Mahmoud M; Jamieson, Kyla C; Joshi, Radhika; Newton, Robert; Giembycz, Mark A

Analysis of the Indacaterol-Regulated Transcriptome in Human Airway Epithelial Cells Implicates Gene Expression Changes in the Adverse and Therapeutic Effects of ß₂-Adrenoceptor Agonists.

Yan, Dong; Hamed, Omar; Joshi, Taruna; Mostafa, Mahmoud M; Jamieson, Kyla C; Joshi, Radhika; Newton, Robert; Giembycz, Mark A.

Afiliação

Yan D; Departments of Physiology and Pharmacology (D.Y., O.H., T.J., K.C.J., R.J., M.A.G.) and Cell Biology and Anatomy (M.M.M., R.N.), Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Hamed O; Departments of Physiology and Pharmacology (D.Y., O.H., T.J., K.C.J., R.J., M.A.G.) and Cell Biology and Anatomy (M.M.M., R.N.), Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Joshi T; Departments of Physiology and Pharmacology (D.Y., O.H., T.J., K.C.J., R.J., M.A.G.) and Cell Biology and Anatomy (M.M.M., R.N.), Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Mostafa MM; Departments of Physiology and Pharmacology (D.Y., O.H., T.J., K.C.J., R.J., M.A.G.) and Cell Biology and Anatomy (M.M.M., R.N.), Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Jamieson KC; Departments of Physiology and Pharmacology (D.Y., O.H., T.J., K.C.J., R.J., M.A.G.) and Cell Biology and Anatomy (M.M.M., R.N.), Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Joshi R; Departments of Physiology and Pharmacology (D.Y., O.H., T.J., K.C.J., R.J., M.A.G.) and Cell Biology and Anatomy (M.M.M., R.N.), Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Newton R; Departments of Physiology and Pharmacology (D.Y., O.H., T.J., K.C.J., R.J., M.A.G.) and Cell Biology and Anatomy (M.M.M., R.N.), Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Giembycz MA; Departments of Physiology and Pharmacology (D.Y., O.H., T.J., K.C.J., R.J., M.A.G.) and Cell Biology and Anatomy (M.M.M., R.N.), Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada giembycz@ucalgary.ca.

J Pharmacol Exp Ther ; 366(1): 220-236, 2018 07.

Article em En | MEDLINE | ID: mdl-29653961

Assuntos

Agonistas de Receptores Adrenérgicos beta 2/farmacologia; Brônquios/citologia; Células Epiteliais/efeitos dos fármacos; Células Epiteliais/metabolismo; Indanos/farmacologia; Quinolonas/farmacologia; Receptores Adrenérgicos beta 2/metabolismo; Transcriptoma/efeitos dos fármacos; Agonistas de Receptores Adrenérgicos beta 2/efeitos adversos; Agonistas de Receptores Adrenérgicos beta 2/uso terapêutico; Linhagem Celular; AMP Cíclico/metabolismo; Humanos; Indanos/efeitos adversos; Indanos/uso terapêutico; Quinolonas/efeitos adversos; Quinolonas/uso terapêutico; Fatores de Tempo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Brônquios / Receptores Adrenérgicos beta 2 / Quinolonas / Células Epiteliais / Agonistas de Receptores Adrenérgicos beta 2 / Transcriptoma / Indanos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Pharmacol Exp Ther Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Canadá

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