Entamoeba histolytica L220 induces the in vitro activation of macrophages and neutrophils and is modulated by neurotransmitters.
Acta Parasitol
; 63(2): 270-279, 2018 Jun 26.
Article
em En
| MEDLINE
| ID: mdl-29654688
ABSTRACT
The neuroimmunoregulation of inflammation has been well characterized. Entamoeba histolytica provokes an inflammatory response in the host in which macrophages and neutrophils are the first line of defense. The aim of this study was to analyze the effect of the 220 kDa lectin of Entamoeba histolytica on stimulation of human macrophages and neutrophils, especially the secretion of cytokines and the relation of these to neurotransmitters. Human cells were interacted with L220, epinephrine, nicotine, esmolol and vecuronium bromide. The concentrations of IL-1ß, IFN-γ, TNF-α and IL-10 were determined by ELISA at, 4 h of interaction. L220 has a cytokine stimulating function of macrophages and neutrophils for secretion of IL-1ß, and IL-10 only by macrophages, which was modulated by the effect of vecuronium on cholinergic receptors in this immune cells.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Protozoários
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Ativação de Neutrófilo
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Neurotransmissores
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Entamoeba histolytica
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Ativação de Macrófagos
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Macrófagos
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Neutrófilos
Limite:
Adolescent
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Adult
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Humans
Idioma:
En
Revista:
Acta Parasitol
Ano de publicação:
2018
Tipo de documento:
Article