High circulatory leptin mediated NOX-2-peroxynitrite-miR21 axis activate mesangial cells and promotes renal inflammatory pathology in nonalcoholic fatty liver disease.

Alhasson, Firas; Seth, Ratanesh Kumar; Sarkar, Sutapa; Kimono, Diana A; Albadrani, Muayad S; Dattaroy, Diptadip; Chandrashekaran, Varun; Scott, Geoffrey I; Raychoudhury, Samir; Nagarkatti, Mitzi; Nagarkatti, Prakash; Diehl, Anna Mae; Chatterjee, Saurabh

Alhasson, Firas; Seth, Ratanesh Kumar; Sarkar, Sutapa; Kimono, Diana A; Albadrani, Muayad S; Dattaroy, Diptadip; Chandrashekaran, Varun; Scott, Geoffrey I; Raychoudhury, Samir; Nagarkatti, Mitzi; Nagarkatti, Prakash; Diehl, Anna Mae; Chatterjee, Saurabh.

Afiliação

Alhasson F; Environmental Health and Disease Laboratory, Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
Seth RK; Environmental Health and Disease Laboratory, Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
Sarkar S; Environmental Health and Disease Laboratory, Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
Kimono DA; Environmental Health and Disease Laboratory, Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
Albadrani MS; Environmental Health and Disease Laboratory, Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
Dattaroy D; Environmental Health and Disease Laboratory, Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
Chandrashekaran V; Environmental Health and Disease Laboratory, Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
Scott GI; Environmental Health and Disease Laboratory, Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
Raychoudhury S; Department of Biology, Chemistry and Environmental Health Science, Benedict College, Columbia, SC 29204, USA.
Nagarkatti M; Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, SC, USA.
Nagarkatti P; Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, SC, USA.
Diehl AM; Division of Gastroenterology, Duke University, Durham, NC 27707, USA.
Chatterjee S; Environmental Health and Disease Laboratory, Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA. Electronic address: schatt@mailbox.sc.edu.

Redox Biol ; 17: 1-15, 2018 07.

Article em En | MEDLINE | ID: mdl-29660503

Assuntos

Inflamação/genética; MicroRNAs/genética; NADPH Oxidase 2/genética; Hepatopatia Gordurosa não Alcoólica/genética; ATPases Associadas a Diversas Atividades Celulares/genética; Animais; DNA Helicases/genética; Dieta Hiperlipídica; Humanos; Inflamação/metabolismo; Inflamação/patologia; Janus Quinases/genética; Rim/metabolismo; Rim/patologia; Leptina/genética; Células Mesangiais/metabolismo; Células Mesangiais/patologia; Camundongos; Camundongos Knockout; Hepatopatia Gordurosa não Alcoólica/metabolismo; Hepatopatia Gordurosa não Alcoólica/patologia; Estresse Oxidativo/genética; Ácido Peroxinitroso/metabolismo; Fatores de Transcrição STAT/genética; Transdução de Sinais/genética

Palavras-chave

JAK/STAT; Leptin; Mesangial cells; NADPH; NAFLD; NOX-2; Oxidative stress; miR21; siRNA

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: MicroRNAs / Hepatopatia Gordurosa não Alcoólica / NADPH Oxidase 2 / Inflamação Limite: Animals / Humans Idioma: En Revista: Redox Biol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos

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