Can concurrent high-risk endometrial carcinoma occur with atypical endometrial hyperplasia?
Int J Surg
; 53: 350-353, 2018 May.
Article
em En
| MEDLINE
| ID: mdl-29665453
ABSTRACT
BACKGROUND:
This study investigated the frequency of high-risk cancer types in hysterectomy material obtained from patients who were diagnosed with atypical endometrial hyperplasia (AEH) by endometrial sampling. MATERIALS ANDMETHODS:
A total of 227 patients with AEH were retrospectively included in the study. Hysterectomy material was examined as both perioperative frozen section (FS) and paraffin-embedded permanent section (PS). Grade III tumors, grade II tumors larger than 2â¯cm, over 50% myometrial invasion, cervical involvement, and serous or clear cell histology were considered high-risk.RESULTS:
In final pathology, 57 (25.1%) patients had endometrial cancer and 7 (3%) patients had high-risk cancer. Overall analysis of FS/PS agreement yielded a Cohen's Kappa (K) coefficient of 0.420 (moderate agreement). There was moderate (Kâ¯=â¯0.526) agreement between FS and PS in detecting tumor grade, and good agreement (Kâ¯=â¯0.653) in evaluation of myometrial invasion.CONCLUSION:
High-risk endometrial cancer can coexist with AEH. It should be remembered that despite preoperative and FS examinations, these high-risk tumors can be overlooked until final pathology.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias do Endométrio
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Hiperplasia Endometrial
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Secções Congeladas
Tipo de estudo:
Etiology_studies
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Observational_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Middle aged
Idioma:
En
Revista:
Int J Surg
Ano de publicação:
2018
Tipo de documento:
Article