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The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia.
Stein, Eytan M; Garcia-Manero, Guillermo; Rizzieri, David A; Tibes, Raoul; Berdeja, Jesus G; Savona, Michael R; Jongen-Lavrenic, Mojca; Altman, Jessica K; Thomson, Blythe; Blakemore, Stephen J; Daigle, Scott R; Waters, Nigel J; Suttle, A Benjamin; Clawson, Alicia; Pollock, Roy; Krivtsov, Andrei; Armstrong, Scott A; DiMartino, Jorge; Hedrick, Eric; Löwenberg, Bob; Tallman, Martin S.
Afiliação
  • Stein EM; Memorial Sloan Kettering Cancer Center, New York, NY.
  • Garcia-Manero G; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Rizzieri DA; Duke University Medical Center, Durham, NC.
  • Tibes R; Mayo Clinic Scottsdale Arizona, Scottsdale, AZ.
  • Berdeja JG; Sarah Cannon Research Institute, Nashville, TN.
  • Savona MR; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN.
  • Jongen-Lavrenic M; Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Altman JK; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL.
  • Thomson B; Epizyme, Inc., Cambridge, MA.
  • Blakemore SJ; Epizyme, Inc., Cambridge, MA.
  • Daigle SR; Epizyme, Inc., Cambridge, MA.
  • Waters NJ; Epizyme, Inc., Cambridge, MA.
  • Suttle AB; Epizyme, Inc., Cambridge, MA.
  • Clawson A; Epizyme, Inc., Cambridge, MA.
  • Pollock R; Epizyme, Inc., Cambridge, MA.
  • Krivtsov A; Dana-Farber Cancer Institute, Boston, MA; and.
  • Armstrong SA; Dana-Farber Cancer Institute, Boston, MA; and.
  • DiMartino J; Celgene, San Francisco, CA.
  • Hedrick E; Epizyme, Inc., Cambridge, MA.
  • Löwenberg B; Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Tallman MS; Memorial Sloan Kettering Cancer Center, New York, NY.
Blood ; 131(24): 2661-2669, 2018 06 14.
Article em En | MEDLINE | ID: mdl-29724899
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzimidazóis / Histonas / Leucemia Mieloide Aguda / Metiltransferases / Antineoplásicos Tipo de estudo: Clinical_trials Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Blood Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzimidazóis / Histonas / Leucemia Mieloide Aguda / Metiltransferases / Antineoplásicos Tipo de estudo: Clinical_trials Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Blood Ano de publicação: 2018 Tipo de documento: Article