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Contemporary assessment of the correlation between Bosniak classification and histological characteristics of surgically removed atypical renal cysts (UroCCR-12 study).
Nouhaud, François-Xavier; Bernhard, Jean-Christophe; Bigot, Pierre; Khene, Zine-Eddine; Audenet, François; Lang, Herve; Bergerat, Sebastien; Fraisse, Guillaume; Grenier, Nicolas; Cornelis, François; Nedelcu, Cosmina; Béjar, Sofiane; Fromont-Hankard, Gaëlle; Allory, Yves; Lindner, Véronique; Verkarre, Virginie; Daniel, Laurent; Yacoub, Mokrane; Correas, Jean-Michel; Méjean, Arnaud; Rioux-Leclercq, Nathalie; Bensalah, Karim.
Afiliação
  • Nouhaud FX; Department of Urology, Rouen University Hospital, 1 rue de Germont, 76000, Rouen, France. fx_nouhaud@hotmail.fr.
  • Bernhard JC; Department of Urology, Bordeaux University Hospital, Bordeaux, France.
  • Bigot P; Department of Urology, Angers University Hospital, Angers, France.
  • Khene ZE; Department of Urology, Rennes University Hospital, Rennes, France.
  • Audenet F; Department of Urology, European Georges Pompidou Hospital, APHP, Paris, France.
  • Lang H; Department of Urology, Strasbourg University Hospital, Strasbourg, France.
  • Bergerat S; Department of Urology, Strasbourg University Hospital, Strasbourg, France.
  • Fraisse G; Department of Urology, European Georges Pompidou Hospital, APHP, Paris, France.
  • Grenier N; Department of Radiology, Bordeaux University Hospital, Bordeaux, France.
  • Cornelis F; Department of Radiology, Bordeaux University Hospital, Bordeaux, France.
  • Nedelcu C; Department of Radiology, Angers Urology Hospital, Angers, France.
  • Béjar S; Department of Radiology, Rouen University Hospital, Rouen, France.
  • Fromont-Hankard G; Department of Pathology, Tours University Hospital, Tours, France.
  • Allory Y; Department of Pathology, Henry Mondor University Hospital, APHP, Créteil, France.
  • Lindner V; Department of Pathology, Strasbourg University Hospital, Strasbourg, France.
  • Verkarre V; Department of Pathology, European Georges Pompidou Hospital, APHP, Paris, France.
  • Daniel L; Department of Pathology, Timone University Hospital, APHM, Marseille, France.
  • Yacoub M; Department of Pathology, Bordeaux University Hospital, Bordeaux, France.
  • Correas JM; Department of Radiology, European Georges Pompidou Hospital, APHP, Paris, France.
  • Méjean A; Department of Urology, European Georges Pompidou Hospital, APHP, Paris, France.
  • Rioux-Leclercq N; Department of Pathology, Rennes University Hospital, Rennes, France.
  • Bensalah K; Department of Urology, Rennes University Hospital, Rennes, France.
World J Urol ; 36(10): 1643-1649, 2018 Oct.
Article em En | MEDLINE | ID: mdl-29730837
ABSTRACT

PURPOSE:

To evaluate and compare pathological characteristics of renal cysts Bosniak IIF, III and IV in light of recent histological classification. PATIENTS AND

METHODS:

The French research network for kidney cancer UroCCR conducted a multicentre study on patients treated surgically for a renal cyst between 2007 and 2016. Independent radiological and centralized pathological reviews were performed for every patient. Pathological characteristics were compared to the Bosniak classification.

RESULTS:

Of a total 216 patients included, 175 (81.0%) tumours (90.9% of Bosniak IV, 69.8% of Bosniak III) were malignant or had a low malignant potential, with 60% of clear cell renal cell carcinoma (CCRCC), 24% of papillary RCC (PRCC) and 6.9% of multilocular cystic renal tumour of low malignant potential (MCRTLMP). Malignancies were mostly of low pT stage (86.4% of pT1-2), and low ISUP grade (68.0% of 1-2). Bosniak III cysts had a lower rate of CCRCC (46.7 vs. 67.3%), higher rate of PRCC (30 vs. 20.9%) and MCRTLMP (18.3 vs. 0.9%) compared to Bosniak IV (p < 0.001). Low-malignant potential lesions were less likely Bosniak IV and pT3-4 stage was more frequent in Bosniak IV vs. III (15.7 vs. 3.5%; p = 0.04). There were two recurrences (1.1%) and no cancer-related death occurred during follow-up.

CONCLUSION:

These results confirmed that cystic renal malignancies have excellent prognosis. Bosniak III cysts had a low malignant potential, which suggests surveillance could be an option for these lesions.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma de Células Renais / Doenças Renais Císticas / Neoplasias Renais Tipo de estudo: Observational_studies / Prognostic_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: World J Urol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: França

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma de Células Renais / Doenças Renais Císticas / Neoplasias Renais Tipo de estudo: Observational_studies / Prognostic_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: World J Urol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: França