Assessment of the mode of action underlying development of forestomach tumors in rodents following oral exposure to ethyl acrylate and relevance to humans.

Thompson, Chad M; Suh, Mina; Proctor, Deborah M; Chappell, Grace; Borghoff, Susan; Ellis-Hutchings, Robert; Wiench, Karin; Finch, Lavorgie

Thompson, Chad M; Suh, Mina; Proctor, Deborah M; Chappell, Grace; Borghoff, Susan; Ellis-Hutchings, Robert; Wiench, Karin; Finch, Lavorgie.

Afiliação

Thompson CM; ToxStrategies, Inc., Katy, TX 77494, United States.
Suh M; ToxStrategies, Inc., Mission Viejo, CA 92692, United States.
Proctor DM; ToxStrategies, Inc., Mission Viejo, CA 92692, United States.
Chappell G; ToxStrategies, Inc., Austin, TX 78731, United States.
Borghoff S; ToxStrategies, Inc., Cary, NC 27511, United States.
Ellis-Hutchings R; The Dow Chemical Company, Midland, MI 48674, United States.
Wiench K; BASF SE, Ludwigshafen am Rhein Germany.
Finch L; Arkema Inc., King of Prussia, PA 19406, United States. Electronic address: lavorgie.finch@arkema.com.

Regul Toxicol Pharmacol ; 96: 178-189, 2018 Jul.

Article em En | MEDLINE | ID: mdl-29738809

Assuntos

Acrilatos/administração & dosagem; Acrilatos/toxicidade; Neoplasias Gástricas/induzido quimicamente; Acrilatos/química; Administração Oral; Animais; Humanos; Estrutura Molecular; Ratos

Palavras-chave

Carcinogenesis; Ethyl acrylate; Forestomach; Mode of action (MOA); Risk assessment

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / Acrilatos Tipo de estudo: Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Regul Toxicol Pharmacol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos

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