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Multispecies probiotics combination prevents ovalbumin-induced airway hyperreactivity in mice.
Chen, Jui-Cheng; Tsai, Cheng-Chih; Hsieh, Chang-Chi; Lan, Alice; Huang, Chun-Chih; Leu, Sew-Fen.
Afiliação
  • Chen JC; Department of Food Science and Technology, HungKuang University, Taichung, Taiwan.
  • Tsai CC; Department of Food Science and Technology, HungKuang University, Taichung, Taiwan.
  • Hsieh CC; Department of Animal Science and Biotechnology, Tunghai University, Taichung, Taiwan.
  • Lan A; New Bellus Enterprises Co., Ltd., 48 Industrial Road, Tainan City 72042, Taiwan.
  • Huang CC; New Bellus Enterprises Co., Ltd., 48 Industrial Road, Tainan City 72042, Taiwan.
  • Leu SF; Department of Food Science and Technology, HungKuang University, Taichung, Taiwan. Electronic address: sfleu@hk.edu.tw.
Allergol Immunopathol (Madr) ; 46(4): 354-360, 2018.
Article em En | MEDLINE | ID: mdl-29739682
BACKGROUND: Probiotics could be beneficial to health and some of them have shown to modulate immune responses. AIM: The aim of this study is to investigate if the probiotic strains including Lactobacillus and Pediococcus strains are able to alleviate allergic reactions in an ovalbumin-induced airway allergy model. METHODS: Lactobacillus multi-species preparation (LMP) was gavaged to BALB/c for total six weeks and BALB/c was challenged with ovalbumin in the last two weeks. A barometric whole-body plethysmography was used to assess enhanced pause (Penh) of airway hyperreactivity (AHR). Immunoglobulins (Ig) such as IgE, IgG1, IgG2a and cytokines such as IL-12, IFN-γ, IL-4, IL-5, TNF-α and IL-13 in bronchoalveolar lavage fluid were assayed using ELISA kits. RESULTS: The results showed this LMP significantly reduced Th2 cytokines and enhanced Th1 cytokines production. OVA-specific IgE and IgG1 was lower in the probiotics-treated mice whereas IgG2a was increased. Most importantly, this murine model showed LMP supplementation significantly reduced AHR. CONCLUSIONS: Overall, this Lactobacillus multi-species preparation seemed to suppress OVA-sensitized airway hyperreactivity, thus serving as a possible candidate for therapeutic uses for allergic airway symptoms.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hiper-Reatividade Brônquica / Probióticos / Pulmão Limite: Animals Idioma: En Revista: Allergol Immunopathol (Madr) Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Taiwan

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hiper-Reatividade Brônquica / Probióticos / Pulmão Limite: Animals Idioma: En Revista: Allergol Immunopathol (Madr) Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Taiwan