Design and synthesis of new antitumor agents with the 1,7-epoxycyclononane framework. Study of their anticancer action mechanism by a model compound.
Bioorg Med Chem
; 26(12): 3379-3398, 2018 07 23.
Article
em En
| MEDLINE
| ID: mdl-29784272
Palavras-chave
AFM; Aldol cyclization; Anticancer agents; Apoptosis; Apoptotic nuclei; Beta-fragmentation; Circular dichroism; Cytotoxicity; Electrophoresis; Flow cytometry; Fluorescence microscopy; HL-60; Hypoiodite reaction; Lipinski and Veber's rules; MCF-7; Microtubules; Nicholas reaction; Physalins; Synthesis of 1,7-epoxycyclononanes; [4+3]Cycloaddition
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Desenho de Fármacos
/
Cicloparafinas
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2018
Tipo de documento:
Article