Lithium incorporation in the fibroblasts of manic-depressives.
Biol Psychiatry
; 20(1): 58-65, 1985 Jan.
Article
em En
| MEDLINE
| ID: mdl-2981128
ABSTRACT
Lithium incorporation in cultured human skin fibroblasts was measured in a group of 10 manic-depressives and 10 controls. This system was believed to eliminate many of the sources of variability to which measurement of the lithium ratio in erythrocytes (RBCs) is subject. A fibroblast lithium ratio calculated from 1-hr lithium incorporation studies correlated highly with an in vitro RBC lithium ratio in medication-free controls. Manic-depressives and controls did not differ in lithium incorporation or fibroblast lithium ratio, leading to the conclusion that the lithium ratio is probably not a good measure for differentiating the two populations.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtorno Bipolar
/
Cloretos
/
Eritrócitos
/
Fibroblastos
/
Lítio
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Biol Psychiatry
Ano de publicação:
1985
Tipo de documento:
Article