[Synthesis and biological evaluation of 12-N-benzenesulfonyl matrinic ether derivatives as anti-coxsackievirus B3 agents].
Yao Xue Xue Bao
; 51(4): 606-12, 2016 04.
Article
em Zh
| MEDLINE
| ID: mdl-29859656
ABSTRACT
12-N-m-Cyanobenzenesulfonyl matrinic butyl methyl ether is a potent anti-coxsackievirus B3ï¼CVB3ï¼ agent bearing a novel structure skeleton. Taking this compound as a lead, totally 15 novel target compounds have been synthesized and evaluated for the anti-CVB3 activities using CPE method. Structure- activity relationshipï¼SARï¼demonstrated that the shorten-length of 11-side chain was not helpful for keeping the good anti-virus activity. Among the newly synthesized compounds, compound c1 displayed a good anti-CVB3 activity with the IC(50) of 7.1 µmol·L(-1) and SI of 35.5, similar to that of the lead. The SAR results provided useful information for further optimization of these compounds in the molecular structure.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Enterovirus Humano B
/
Éteres
Idioma:
Zh
Revista:
Yao Xue Xue Bao
Ano de publicação:
2016
Tipo de documento:
Article