Surfactant Lung Lavage vs. Standard Care in the Treatment of Meconium Aspiration Syndrome-A Randomized Trial.
J Trop Pediatr
; 65(2): 114-121, 2019 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-29878264
ABSTRACT
OBJECTIVE:
The objective of this study was to evaluate the effect of surfactant lung lavage (SLL) on duration of respiratory support in neonates with meconium aspiration syndrome (MAS). PATIENTS ANDMETHODS:
Sixty term infants with MAS who had moderate to severe respiratory distress (Downes score >4) were randomized toSLL (n = 31) or no lung lavage-NLL (n = 29). Neonates in intervention group underwent lung lavage with dilute surfactant and those in control group were managed as per unit protocol.RESULTS:
The median duration of respiratory support was 34 h in SLL group and 44 h in NLL group (p value = 0.994). The duration of oxygen therapy post-respiratory support decreased by 78% in SLL as compared with NLL group (4 vs. 18 h) (p value = 0.005). Lavage procedure was well tolerated with fall in mean heart rate by just 20/min and in mean saturation drop by just 6% during the procedure.CONCLUSION:
Lung lavage is well tolerated by neonates, but it does not alter overall duration of respiratory support.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Produtos Biológicos
/
Surfactantes Pulmonares
/
Síndrome de Aspiração de Mecônio
/
Lavagem Broncoalveolar
Tipo de estudo:
Clinical_trials
/
Guideline
Limite:
Female
/
Humans
/
Male
/
Newborn
País/Região como assunto:
Asia
Idioma:
En
Revista:
J Trop Pediatr
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Índia