Epigenetic Editing: Repurposing for Rescue.
Trends Biochem Sci
; 43(8): 561-563, 2018 08.
Article
em En
| MEDLINE
| ID: mdl-29910019
ABSTRACT
The epigenome editing framework provides an engineering approach to explore chromatin-based gene expression mechanisms. However, therapeutic utility of epigenetic editing-based systems has been lacking. A report in Cell (Liu et. al., 2018) shows that epigenetic editors can revert abnormal heterochromatin formation at the gene promoter leading to restoration of FMR1 gene expression, functionally rescuing fragile X syndrome (FXS), an otherwise unamenable genetic disorder.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndrome do Cromossomo X Frágil
Limite:
Humans
Idioma:
En
Revista:
Trends Biochem Sci
Ano de publicação:
2018
Tipo de documento:
Article