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Pro: Steroids Can Be Withdrawn After Transplant in Recipients With Autoimmune Hepatitis.
Kalra, Avash; Burton, James R; Forman, Lisa M.
Afiliação
  • Kalra A; Division of Gastroenterology and Hepatology, University of Colorado, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO.
  • Burton JR; Division of Gastroenterology and Hepatology, University of Colorado, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO.
  • Forman LM; Division of Gastroenterology and Hepatology, University of Colorado, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO.
Liver Transpl ; 24(8): 1109-1112, 2018 08.
Article em En | MEDLINE | ID: mdl-29923302
Corticosteroids have been a mainstay of immunosuppression following liver transplantation. However, evolution in the field of transplant immunology has produced steroid-free options, resulting in most transplant centers weaning steroids after transplant within days to months-an evidence-based management decision. Patients with autoimmune hepatitis (AIH), however, receive corticosteroids prior to transplant. This raises the question of whether these patients should also be weaned from corticosteroids. In this review, we discuss the benefits of avoiding steroid use in this population of patients-an approach that not only avoids the adverse effects of corticosteroids but does so without risking graft failure from recurrent AIH or from acute cellular rejection.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Terapia de Imunossupressão / Transplante de Fígado / Hepatite Autoimune / Glucocorticoides / Rejeição de Enxerto Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Liver Transpl Assunto da revista: GASTROENTEROLOGIA / TRANSPLANTE Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Terapia de Imunossupressão / Transplante de Fígado / Hepatite Autoimune / Glucocorticoides / Rejeição de Enxerto Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Liver Transpl Assunto da revista: GASTROENTEROLOGIA / TRANSPLANTE Ano de publicação: 2018 Tipo de documento: Article