A Glutamine-Rich Carrier Efficiently Delivers Anti-CD47 siRNA Driven by a "Glutamine Trap" To Inhibit Lung Cancer Cell Growth.

Wu, Jiamin; Li, Zhi; Yang, Zeping; Guo, Ling; Zhang, Ye; Deng, Huihui; Wang, Cuifeng; Feng, Min

Wu, Jiamin; Li, Zhi; Yang, Zeping; Guo, Ling; Zhang, Ye; Deng, Huihui; Wang, Cuifeng; Feng, Min.

Afiliação

Wu J; Department of Pharmacy, School of Pharmaceutical Sciences , Sun Yat-sen University , University Town, Guangzhou , P. R. China 510006.
Li Z; Department of Pharmacy, School of Pharmaceutical Sciences , Sun Yat-sen University , University Town, Guangzhou , P. R. China 510006.
Yang Z; Department of Pharmacy, School of Pharmaceutical Sciences , Sun Yat-sen University , University Town, Guangzhou , P. R. China 510006.
Guo L; Department of Pharmacy, School of Pharmaceutical Sciences , Sun Yat-sen University , University Town, Guangzhou , P. R. China 510006.
Zhang Y; Department of Pharmacy, School of Pharmaceutical Sciences , Sun Yat-sen University , University Town, Guangzhou , P. R. China 510006.
Deng H; Department of Pharmacy, School of Pharmaceutical Sciences , Sun Yat-sen University , University Town, Guangzhou , P. R. China 510006.
Wang C; Department of Pharmacy, School of Pharmaceutical Sciences , Sun Yat-sen University , University Town, Guangzhou , P. R. China 510006.
Feng M; Department of Pharmacy, School of Pharmaceutical Sciences , Sun Yat-sen University , University Town, Guangzhou , P. R. China 510006.

Mol Pharm ; 15(8): 3032-3045, 2018 08 06.

Article em En | MEDLINE | ID: mdl-29939755

Assuntos

Antígeno CD47/antagonistas & inibidores; Portadores de Fármacos/química; Neoplasias Pulmonares/tratamento farmacológico; RNA Interferente Pequeno/administração & dosagem; Células A549; Sistema ASC de Transporte de Aminoácidos/antagonistas & inibidores; Sistema ASC de Transporte de Aminoácidos/metabolismo; Animais; Antígeno CD47/genética; Dipeptídeos/farmacologia; Fibroblastos; Glutamina/análogos & derivados; Glutamina/metabolismo; Humanos; Neoplasias Pulmonares/patologia; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; Antígenos de Histocompatibilidade Menor/metabolismo; Polietilenoimina/química; RNA Interferente Pequeno/genética; Cloridrato de Raloxifeno/farmacologia; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

CD47; cancer immunotherapy; glutamine transporter ASCT2; glutamine trap; glutamine-dependent lung cancer

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Portadores de Fármacos / RNA Interferente Pequeno / Antígeno CD47 / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Mol Pharm Assunto da revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Ano de publicação: 2018 Tipo de documento: Article

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