Label-free cell signaling pathway deconvolution of angiotensin type 1 receptor reveals time-resolved G-protein activity and distinct AngII and AngIIIIV responses.

Lavenus, Sandrine; Simard, Élie; Besserer-Offroy, Élie; Froehlich, Ulrike; Leduc, Richard; Grandbois, Michel

Lavenus, Sandrine; Simard, Élie; Besserer-Offroy, Élie; Froehlich, Ulrike; Leduc, Richard; Grandbois, Michel.

Afiliação

Lavenus S; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Québec, J1H5N4, Canada; Institut de pharmacologie de Sherbrooke, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Québec, J1H5N4, Canada. Electronic add
Simard É; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Québec, J1H5N4, Canada; Institut de pharmacologie de Sherbrooke, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Québec, J1H5N4, Canada. Electronic add
Besserer-Offroy É; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Québec, J1H5N4, Canada; Institut de pharmacologie de Sherbrooke, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Québec, J1H5N4, Canada. Electronic add
Froehlich U; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Québec, J1H5N4, Canada; Institut de pharmacologie de Sherbrooke, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Québec, J1H5N4, Canada. Electronic add
Leduc R; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Québec, J1H5N4, Canada; Institut de pharmacologie de Sherbrooke, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Québec, J1H5N4, Canada. Electronic add
Grandbois M; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Québec, J1H5N4, Canada; Institut de pharmacologie de Sherbrooke, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Québec, J1H5N4, Canada. Electronic add

Pharmacol Res ; 136: 108-120, 2018 10.

Article em En | MEDLINE | ID: mdl-29959993

Assuntos

Angiotensina II/análogos & derivados; Angiotensina II/farmacologia; Proteínas de Ligação ao GTP/fisiologia; Receptor Tipo 1 de Angiotensina/fisiologia; Células HEK293; Humanos; RNA Interferente Pequeno/genética; Transdução de Sinais; Ressonância de Plasmônio de Superfície

Palavras-chave

AngII (PubChem CID: 172198); AngIII (PubChem CID: 3082042); AngIV (PubChem CID: 123814); Angiotensin II (AngII); Angiotensin type 1 receptor (AT(1)R); G protein-coupled receptors (GPCR); G proteins; Surface plasmon resonance (SPR); TRV120027 (PubChem CID: 3082475); [Sar(1), Ile(8)]AngII (PubChem CID: 10079601); [Sar(1)]AngII (PubChem CID: 10373777); ß-arrestins

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Angiotensina II / Proteínas de Ligação ao GTP / Receptor Tipo 1 de Angiotensina Limite: Humans Idioma: En Revista: Pharmacol Res Assunto da revista: FARMACOLOGIA Ano de publicação: 2018 Tipo de documento: Article

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