Strand-Specific Dual RNA Sequencing of Bronchial Epithelial Cells Infected with Influenza A/H3N2 Viruses Reveals Splicing of Gene Segment 6 and Novel Host-Virus Interactions.

Fabozzi, Giulia; Oler, Andrew J; Liu, Poching; Chen, Yong; Mindaye, Samuel; Dolan, Michael A; Kenney, Heather; Gucek, Marjan; Zhu, Jun; Rabin, Ronald L; Subbarao, Kanta

Fabozzi, Giulia; Oler, Andrew J; Liu, Poching; Chen, Yong; Mindaye, Samuel; Dolan, Michael A; Kenney, Heather; Gucek, Marjan; Zhu, Jun; Rabin, Ronald L; Subbarao, Kanta.

Afiliação

Fabozzi G; Laboratory of Immunobiochemistry, Division of Bacterial, Parasitic and Allergenic Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
Oler AJ; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Liu P; Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Chen Y; Systems Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Mindaye S; Proteomics Core, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Dolan MA; Laboratory of Immunobiochemistry, Division of Bacterial, Parasitic and Allergenic Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
Kenney H; Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Gucek M; Emerging Respiratory Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Zhu J; Proteomics Core, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Rabin RL; Systems Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Subbarao K; Laboratory of Immunobiochemistry, Division of Bacterial, Parasitic and Allergenic Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA ronald.rabin@fda.hhs.gov KSUBBARAO@niaid.nih.gov.

J Virol ; 92(17)2018 09 01.

Article em En | MEDLINE | ID: mdl-29976658

Assuntos

Genoma Humano/genética; Genoma Viral/genética; Interações Hospedeiro-Patógeno/genética; Imunidade Inata/genética; Vírus da Influenza A Subtipo H3N2/genética; Influenza Humana/imunologia; Brônquios/citologia; Brônquios/virologia; Células Epiteliais/virologia; Perfilação da Expressão Gênica; Glicoproteínas de Hemaglutininação de Vírus da Influenza/genética; Interações Hospedeiro-Patógeno/imunologia; Humanos; Vírus da Influenza A Subtipo H3N2/imunologia; Influenza Humana/virologia; Neuraminidase/genética; Splicing de RNA/genética; Estações do Ano; Análise de Sequência de RNA/métodos

Palavras-chave

Udorn/72 strain; alternative splicing; bronchial epithelial cells; dual RNA-seq; host-virus interaction; influenza A virus H3N2; neuraminidase; seasonal H3N2 strains; strand-specific RNA seq; viral transcriptome

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Genoma Humano / Genoma Viral / Influenza Humana / Vírus da Influenza A Subtipo H3N2 / Interações Hospedeiro-Patógeno / Imunidade Inata Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Virol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos

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