Dermatan sulfate epimerase 1 and dermatan 4-<i>O</i>-sulfotransferase 1 form complexes that generate long epimerized 4-<i>O</i>-sulfated blocks.

Tykesson, Emil; Hassinen, Antti; Zielinska, Katarzyna; Thelin, Martin A; Frati, Giacomo; Ellervik, Ulf; Westergren-Thorsson, Gunilla; Malmström, Anders; Kellokumpu, Sakari; Maccarana, Marco

Dermatan sulfate epimerase 1 and dermatan 4-O-sulfotransferase 1 form complexes that generate long epimerized 4-O-sulfated blocks.

Tykesson, Emil; Hassinen, Antti; Zielinska, Katarzyna; Thelin, Martin A; Frati, Giacomo; Ellervik, Ulf; Westergren-Thorsson, Gunilla; Malmström, Anders; Kellokumpu, Sakari; Maccarana, Marco.

Afiliação

Tykesson E; From the Department of Experimental Medical Science, Lund University, SE-221 00, Lund, Sweden.
Hassinen A; Faculty of Biochemistry and Molecular Medicine, University of Oulu, 90570 Oulu, Finland.
Zielinska K; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland, and.
Thelin MA; From the Department of Experimental Medical Science, Lund University, SE-221 00, Lund, Sweden.
Frati G; From the Department of Experimental Medical Science, Lund University, SE-221 00, Lund, Sweden.
Ellervik U; From the Department of Experimental Medical Science, Lund University, SE-221 00, Lund, Sweden.
Westergren-Thorsson G; Department of Chemistry, Lund University, SE-221 00, Lund, Sweden.
Malmström A; From the Department of Experimental Medical Science, Lund University, SE-221 00, Lund, Sweden.
Kellokumpu S; From the Department of Experimental Medical Science, Lund University, SE-221 00, Lund, Sweden.
Maccarana M; Faculty of Biochemistry and Molecular Medicine, University of Oulu, 90570 Oulu, Finland.

J Biol Chem ; 293(35): 13725-13735, 2018 08 31.

Article em En | MEDLINE | ID: mdl-29976758

Assuntos

Antígenos de Neoplasias/metabolismo; Proteínas de Ligação a DNA/metabolismo; Dermatan Sulfato/metabolismo; Ácido Idurônico/metabolismo; Proteínas de Neoplasias/metabolismo; Sulfotransferases/metabolismo; Animais; Antígenos de Neoplasias/análise; Células COS; Chlorocebus aethiops; Proteínas de Ligação a DNA/análise; Humanos; Proteínas de Neoplasias/análise; Proteínas Recombinantes/análise; Proteínas Recombinantes/metabolismo; Sulfotransferases/análise

Palavras-chave

D4ST1; DS-epi1; DS-epi2; Golgi; chondroitin sulfate; dermatan sulfate; epimerase; epimerization; glycobiology; glycosaminoglycan

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulfotransferases / Dermatan Sulfato / Proteínas de Ligação a DNA / Ácido Idurônico / Antígenos de Neoplasias / Proteínas de Neoplasias Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Suécia

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