Early predictors of diabetic retinopathy in type 1 diabetes: The Retinopathy Champagne Ardenne Diabète (ReCAD) study.
J Diabetes Complications
; 32(8): 753-758, 2018 Aug.
Article
em En
| MEDLINE
| ID: mdl-29980433
ABSTRACT
AIMS:
To determine the relationship between early markers of diabetes control and diabetic retinopathy (DR) in type 1 diabetes.METHODS:
A historic cohort study was conducted on 712 patients from the CARéDIAB database. HbA1c and usual metabolic parameters were measured one year after diagnosis of diabetes. First occurrences of severe hypoglycemia and ketoacidosis during follow-up were selected as time-dependent markers of diabetes control. Data were analyzed in a Cox model using SPSS software to predict DR with significance level at p-value <0.05.RESULTS:
In multivariate regression, any diabetic retinopathy was predicted by HbA1c (HRâ¯=â¯1.38; CIâ¯=â¯1.25-1.52; pâ¯<â¯0.0001), severe hypoglycemia (HRâ¯=â¯3; CIâ¯=â¯1.99-4.52; pâ¯<â¯0.0001), ketoacidosis (HRâ¯=â¯1.96; CIâ¯=â¯1.17-3.22; pâ¯=â¯0.009), and age at diagnosis (HRâ¯=â¯1.016; CIâ¯=â¯1.002-1.031; pâ¯=â¯0.02). Proliferative DR was predicted by HbA1c (HRâ¯=â¯1.67; CIâ¯=â¯1.51-1.79; pâ¯<â¯0.0001), severe hypoglycemia (HRâ¯=â¯3.67; CIâ¯=â¯2.74-5.25; pâ¯<â¯0.0001), and ketoacidosis (HRâ¯=â¯2.37; CIâ¯=â¯1.56-3.18; pâ¯<â¯0.0001).CONCLUSION:
This study shows that the failure to achieve diabetes control after the first year of diagnosis as well as early episodes of acute diabetes complications may contribute to the occurrence of diabetic retinopathy in type 1 diabetes patients.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Diabetes Mellitus Tipo 1
/
Retinopatia Diabética
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limite:
Adolescent
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Adult
/
Child
/
Child, preschool
/
Female
/
Humans
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Infant
/
Male
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Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
J Diabetes Complications
Assunto da revista:
ENDOCRINOLOGIA
Ano de publicação:
2018
Tipo de documento:
Article