Echinocandin Treatment of Candida albicans Biofilms Enhances Neutrophil Extracellular Trap Formation.
Antimicrob Agents Chemother
; 62(9)2018 09.
Article
em En
| MEDLINE
| ID: mdl-29987146
ABSTRACT
The nosocomial pathogen Candida albicans forms biofilms on medical devices that persist in the face of antifungals and host defenses. Echinocandins, the most effective antibiofilm drugs, have recently been shown to augment the activity of neutrophils against biofilms through an unknown mechanism. Here, we show that treatment of C. albicans biofilms with subinhibitory concentrations of echinocandins promotes the formation of neutrophil extracellular traps (NETs), structures of DNA, histones, and antimicrobial proteins with antifungal activity.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Candida albicans
/
Biofilmes
/
Equinocandinas
/
Armadilhas Extracelulares
/
Antifúngicos
/
Neutrófilos
Limite:
Humans
Idioma:
En
Revista:
Antimicrob Agents Chemother
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Estados Unidos