Doxorubicin/gold nanoparticles coated with liposomes for chemo-photothermal synergetic antitumor therapy.
Nanotechnology
; 29(40): 405101, 2018 Oct 05.
Article
em En
| MEDLINE
| ID: mdl-30004030
ABSTRACT
Hybrid liposome/metal nanoparticles are promising candidate drug-carriers for therapy of various diseases due to their unique photothermal effect. In this study, self-crystallized gold nanoparticles (Au NPs) and doxorubicin (DOX) were co-encapsulated within liposomes (Au/DOX-Lips) by thin film hydration and gel separation technology. The surface plasmon resonance bands of drug-carriers were controllable in the near-infrared (NIR) zone. When the complex liposome/metallic hybrids were irradiated by NIR light, they displayed higher endocytosis efficiency following the fracture of liposomal membranes and the release of Au NPs. Then, the Au NPs penetrated further into deeper tumor tissue to accomplish photothermal treatment. The Au/DOX-Lips showed an excellent antitumor effect, whose inhibition rate for tumor cells was up to 78.28%. In experiments on mice bearing tumors, the Au/DOX-Lips treated mice exhibited superior tumor suppression. This novel drug system provides huge potential for biomedical application.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doxorrubicina
/
Ouro
/
Hipertermia Induzida
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Neoplasias Experimentais
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nanotechnology
Ano de publicação:
2018
Tipo de documento:
Article