Drug-delivering-drug platform-mediated potent protein therapeutics <i>via</i> a non-endo-lysosomal route.

Xin, Xiaofei; Teng, Chao; Du, Xiaoqing; Lv, Yaiqi; Xiao, Qingqing; Wu, Yubing; He, Wei; Yin, Lifang

Drug-delivering-drug platform-mediated potent protein therapeutics via a non-endo-lysosomal route.

Xin, Xiaofei; Teng, Chao; Du, Xiaoqing; Lv, Yaiqi; Xiao, Qingqing; Wu, Yubing; He, Wei; Yin, Lifang.

Afiliação

Xin X; Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, PR China.
Teng C; Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, PR China.
Du X; Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, PR China.
Lv Y; Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, PR China.
Xiao Q; Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, PR China.
Wu Y; Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, PR China.
He W; Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, PR China.
Yin L; Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, PR China.

Theranostics ; 8(13): 3474-3489, 2018.

Article em En | MEDLINE | ID: mdl-30026860

Assuntos

Antineoplásicos/farmacocinética; Produtos Biológicos/farmacocinética; Neoplasias da Mama/tratamento farmacológico; Caspase 3/farmacocinética; Sistemas de Liberação de Medicamentos; Nanopartículas/metabolismo; Animais; Antineoplásicos/administração & dosagem; Disponibilidade Biológica; Produtos Biológicos/administração & dosagem; Western Blotting; Caspase 3/administração & dosagem; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Modelos Animais de Doenças; Citometria de Fluxo; Humanos; Camundongos Endogâmicos BALB C; Microscopia Confocal; Modelos Biológicos; Imagem Óptica; Ratos; Resultado do Tratamento

Palavras-chave

caspase 3; caveolae-mediated endocytosis; endo-lysosomes; intracellular protein delivery; rod-like pure drug particles

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Produtos Biológicos / Neoplasias da Mama / Sistemas de Liberação de Medicamentos / Caspase 3 / Nanopartículas / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Theranostics Ano de publicação: 2018 Tipo de documento: Article

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