Discovery of AM-6226: A Potent and Orally Bioavailable GPR40 Full Agonist That Displays Efficacy in Nonhuman Primates.

Brown, Sean P; Dransfield, Paul; Vimolratana, Marc; Zhu, Liusheng; Luo, Jian; Zhang, Jane; Jiao, XianYun; Pattaropong, Vatee; Wong, Simon; Zhuang, Run; Swaminath, Gayathri; Houze, Jonathan B; Lin, Daniel C-H

Brown, Sean P; Dransfield, Paul; Vimolratana, Marc; Zhu, Liusheng; Luo, Jian; Zhang, Jane; Jiao, XianYun; Pattaropong, Vatee; Wong, Simon; Zhuang, Run; Swaminath, Gayathri; Houze, Jonathan B; Lin, Daniel C-H.

Afiliação

Brown SP; Department of Medicinal Chemistry, Amgen Discovery Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Dransfield P; Department of Medicinal Chemistry, Amgen Discovery Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Vimolratana M; Department of Medicinal Chemistry, Amgen Discovery Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Zhu L; Department of Medicinal Chemistry, Amgen Discovery Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Luo J; Department of Medicinal Chemistry, Amgen Discovery Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Zhang J; Department of Medicinal Chemistry, Amgen Discovery Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Jiao X; Department of Medicinal Chemistry, Amgen Discovery Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Pattaropong V; Department of Medicinal Chemistry, Amgen Discovery Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Wong S; Department of Medicinal Chemistry, Amgen Discovery Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Zhuang R; Department of Medicinal Chemistry, Amgen Discovery Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Swaminath G; Department of Medicinal Chemistry, Amgen Discovery Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Houze JB; Department of Medicinal Chemistry, Amgen Discovery Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Lin DC; Department of Medicinal Chemistry, Amgen Discovery Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.

ACS Med Chem Lett ; 9(7): 757-760, 2018 Jul 12.

Article em En | MEDLINE | ID: mdl-30034614

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: ACS Med Chem Lett Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos

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