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Coidentification of mcr-4.3 and blaNDM-1 in a Clinical Enterobacter cloacae Isolate from China.
Chavda, Bhakti; Lv, Jingnan; Hou, Mengyun; Chavda, Kalyan D; Kreiswirth, Barry N; Feng, Youjun; Chen, Liang; Yu, Fangyou.
Afiliação
  • Chavda B; Public Health Research Institute Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
  • Lv J; Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
  • Hou M; Department of Medical Microbiology and Parasitology and Department of General Intensive Care Unit of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
  • Chavda KD; Public Health Research Institute Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
  • Kreiswirth BN; Public Health Research Institute Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
  • Feng Y; Department of Medical Microbiology and Parasitology and Department of General Intensive Care Unit of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China fengyj@zju.edu.cn chen11@njms.rutgers.edu wzjxyfy@163.com.
  • Chen L; Public Health Research Institute Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA fengyj@zju.edu.cn chen11@njms.rutgers.edu wzjxyfy@163.com.
  • Yu F; Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China fengyj@zju.edu.cn chen11@njms.rutgers.edu wzjxyfy@163.com.
Antimicrob Agents Chemother ; 62(10)2018 10.
Article em En | MEDLINE | ID: mdl-30038043
ABSTRACT
We describe the first report of a clinical colistin-resistant ST84 Enterobacter cloacae isolate coharboring mcr-4.3 (previously named mcr-4.2) and blaNDM-1 from a patient in China. The blaNDM-1-harboring IncX3 plasmid and the novel mcr-4.3-harboring ColE plasmid were completely sequenced. Although this isolate showed a high level of resistance to colistin, mcr-4.3 plasmid transformation, gene subcloning, susceptibility testing, and lipid A matrix-assisted laser desorption ionization mass spectrometry analysis indicated that mcr-4.3 itself does not confer resistance to colistin.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Beta-Lactamases / Enterobacter cloacae País/Região como assunto: Asia Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Beta-Lactamases / Enterobacter cloacae País/Região como assunto: Asia Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos