High titers of autoantibodies to topoisomerase I (Scl-70) in sera from scleroderma patients.
Science
; 231(4739): 737-40, 1986 Feb 14.
Article
em En
| MEDLINE
| ID: mdl-3003910
ABSTRACT
Patients with rheumatic diseases often have circulating autoantibodies to nuclear components. The clinical significance of the antibodies is controversial, although in some cases they are valuable in the diagnosis of the disease. This report presents results of a study of Scl-70, an autoantigen recognized by sera of many patients with the most severe form of progressive systemic sclerosis. It was possible to show, by three independent criteria, that Scl-70 is the abundant nuclear enzyme DNA topoisomerase I. Therefore, antibody probes of high titer and high affinity are now available for the study of this important nuclear enzyme.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Escleroderma Sistêmico
/
Autoanticorpos
/
DNA Topoisomerases Tipo I
Limite:
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
1986
Tipo de documento:
Article